““In a young, healthy woman, the estrogen ratio generally averages as follows: 60–80 percent estriol, 10–20 percent estradiol, and 10–20 percent estrone. While these levels vary from one individual to another, the goal of bioidentical hormone restoration therapy (BHRT), discussed later, is to re-create a more natural balance in the levels of estrogen and in combination with all the other sex hormones. Estrogens convert into several metabolites. Estrone, for example, may convert into three different forms: • 2-hydroxyestrone, protective against cancer • 4-hydroxyestrone, promotes cancer • 16-alpha-hydroxyestrone, promotes cancer””
