““Importantly, maternal stress impacts fetal development. There are indirect routes—for example, stressed people consume less healthy diets and consume more substances of abuse. More directly, stress alters maternal blood pressure and immune defenses, which impact a fetus. Most important, stressed mothers secrete glucocorticoids, which enter fetal circulation and basically have the same bad consequences as in stressed infants and children. Glucocorticoids accomplish this through organizational effects on fetal brain construction and decreasing levels of growth factors, numbers of neurons and synapses, and so on. Just as prenatal testosterone exposure generates an adult brain that is more sensitive to environmental triggers of aggression, excessive prenatal glucocorticoid exposure produces an adult brain more sensitive to environmental triggers of depression and anxiety.””
