“Some physiologic responses to acute pain and stress are mediated by neuroendocrine activation and increased sympathetic tone. As a consequence, patients develop tachycardia, increased myocardial oxygen consumption, immunosuppression, hypercoagulability, persistent catabolism, and numerous other metabolic alterations.5” — Jean-Louis Vincent Copy Share Image
“These vascular changes, evident to the clinician by examination of the retina, are mirrored by changes in the kidney, leading to a proliferative arteritis,… — Jean-Louis Vincent Copy Share Image
“7 Severe hemophagocytic syndrome with failure of one or more organs. The choice of cytoreductive regimen depends on the type of malignancy, which is… — Jean-Louis Vincent Copy Share Image
“Nicardipine is metabolized by the liver, and excretion can be impaired in patients with abnormal hepatic function.” — Jean-Louis Vincent Copy Share Image
“Most commonly, hypertensive emergencies occur in the setting of uncontrolled or unknown chronic hypertension. Hypertensive emergencies also may develop as secondary hypertension in association… — Jean-Louis Vincent Copy Share Image
“Newer agents for treatment of seizures in critically ill patients include the phenytoin prodrug, fosphenytoin; the anesthetic agent, propofol; and the water-soluble benzodiazepine, midazolam.” — Jean-Louis Vincent Copy Share Image
“The relationship between BP and mortality in patients with stroke may be “U-shaped.” According to this notion, systolic BP (SBP) values above or below… — Jean-Louis Vincent Copy Share Image
“Although specific treatments for ALI/ARDS have been slow to emerge, the recent development of new strategies for mechanical ventilation that improve mortality, and fluid… — Jean-Louis Vincent Copy Share Image
“Acute pain is triggered by stimulation of peripheral nociceptors in the skin or deeper structures and is a complex process involving multiple mediators at… — Jean-Louis Vincent Copy Share Image
“On the basis of a recent meta-analysis,25,26 continuous peripheral analgesic techniques provide superior analgesia, reduce opioid consumption, and reduce opioid-related side effects (nausea and… — Jean-Louis Vincent Copy Share Image
“Several sedation scales—the Richmond Agitation Sedation Scale (RASS), Adaptation to the Intensive Care Environment (ATICE) tool, and the Minnesota Sedation Assessment Tool (MSAT)—as well… — Jean-Louis Vincent Copy Share Image
“Whenever possible, at least 10 to 15 mL of blood should be withdrawn and inoculated into 2 or 3 bottles or tubes at a ratio… — Jean-Louis Vincent Copy Share Image
“These effects result in depletion of cellular adenosine triphosphate (ATP) and potentially severe detrimental effects on cell function. It is important to note that… — Jean-Louis Vincent Copy Share Image
