“Aortic dissection results from an intimal tear in the aortic wall. The primary morbidity and mortality results from extension of the tear. This extension is promoted by factors that increase the rate of change of aortic pressure (dp/dt), including elevation… — Jean-Louis Vincent Copy Share Image
“These vascular changes, evident to the clinician by examination of the retina, are mirrored by changes in the kidney, leading to a proliferative arteritis,… — Jean-Louis Vincent Copy Share Image
“7 Severe hemophagocytic syndrome with failure of one or more organs. The choice of cytoreductive regimen depends on the type of malignancy, which is not always precisely known on arrival of the patient in the ICU. For acute leukemias, efforts should be made to characterize the lineage (ALL or AML) before treatment is initiated, but if lineage cannot be determined,… — Jean-Louis Vincent Copy Share
“Nicardipine is metabolized by the liver, and excretion can be impaired in patients with abnormal hepatic function.” — Jean-Louis Vincent Copy Share Image
“Most commonly, hypertensive emergencies occur in the setting of uncontrolled or unknown chronic hypertension. Hypertensive emergencies also may develop as secondary hypertension in association… — Jean-Louis Vincent Copy Share Image
“Newer agents for treatment of seizures in critically ill patients include the phenytoin prodrug, fosphenytoin; the anesthetic agent, propofol; and the water-soluble benzodiazepine, midazolam.” — Jean-Louis Vincent Copy Share Image
“The relationship between BP and mortality in patients with stroke may be “U-shaped.” According to this notion, systolic BP (SBP) values above or below 140 to 180 mm Hg are associated with increased mortality. In the International Stroke Trial, SBP above 200 mm Hg was associated with an increased risk of recurrent ischemic stroke (50% greater risk of recurrence), while low BP (particularly <120 mm Hg) was associated with an excess number of deaths from coronary heart disease.” — Jean-Louis Vincent Copy Share
“Although specific treatments for ALI/ARDS have been slow to emerge, the recent development of new strategies for mechanical ventilation that improve mortality, and fluid management strategies that reduce the length of mechanical ventilation, emphasizes the importance of identifying and appropriately treating all patients with ALI/ARDS. Although this point would seem to be straightforward, in practice, ALI/ARDS remains largely underdiagnosed,” — Jean-Louis Vincent Copy Share
“Acute pain is triggered by stimulation of peripheral nociceptors in the skin or deeper structures and is a complex process involving multiple mediators at… — Jean-Louis Vincent Copy Share Image
“On the basis of a recent meta-analysis,25,26 continuous peripheral analgesic techniques provide superior analgesia, reduce opioid consumption, and reduce opioid-related side effects (nausea and… — Jean-Louis Vincent Copy Share Image
“Several sedation scales—the Richmond Agitation Sedation Scale (RASS), Adaptation to the Intensive Care Environment (ATICE) tool, and the Minnesota Sedation Assessment Tool (MSAT)—as well… — Jean-Louis Vincent Copy Share Image
“Whenever possible, at least 10 to 15 mL of blood should be withdrawn and inoculated into 2 or 3 bottles or tubes at a ratio… — Jean-Louis Vincent Copy Share Image
“These effects result in depletion of cellular adenosine triphosphate (ATP) and potentially severe detrimental effects on cell function. It is important to note that… — Jean-Louis Vincent Copy Share Image
