Childhood trauma Quote by Robert M. Sapolsky
““Another gene/environment interaction pertains to depression, a disease involving serotonin abnormalities.33 A gene called 5HTT codes for a transporter that removes serotonin from the synapse; having a particular 5HTT variant increases the risk of depression … but only when coupled with childhood trauma.fn23 What’s the effect of 5HTT variant on depression risk? It depends on childhood trauma exposure. What’s the effect of childhood trauma exposure on depression risk? It depends on 5HTT variant (plus loads of other genes, but you get the point).””
About This Quote
Source Book: Behave: The Biology of Humans at Our Best and Worst, Robert M. Sapolsky, 2017
The impact of a serotonin transporter gene variant on depression risk is amplified by childhood trauma, illustrating gene‑environment interaction.
In simple terms: Depression risk from a gene depends on early trauma.
Key Takeaway
Consider both genetics and environment in mental health.
Themes
genetics
environment
mental health
risk
interaction
Mood
thoughtful
analytical
Type
scientific
educational
When to use this quote
- clinical assessment
- therapy planning
- public health policy
- personal coping strategies
Key Concepts
serotonin transport
gene‑environment interaction
epigenetics
Questions to Reflect On
- How do you assess combined genetic and trauma factors?
- What interventions could mitigate this interaction?
A Different Perspective
Genetic risk alone is insufficient without environmental context.
