“Freud was fascinated with depression and focused on the issue that we began with—why is it that most of us can have occasional terrible experiences, feel depressed, and then recover, while a few of us collapse into major depression (melancholia)?… — Robert M. Sapolsky Copy Share
If I had to define a major depression in a single sentence, I would describe it as a "genetic/neurochemical disorder requiring a strong environmental trigger whose characteristic manifestation is an inability to appreciate sunsets. — Robert M. Sapolsky Copy Share Image
“Secure-attachment 7Rs show more generosity than average. Thus 7R has something to do with generosity—but its effect is entirely context dependent.” — Robert M. Sapolsky Copy Share Image
But if you get chronically, psychosocially stressed, you're going to compromise your health. So, essentially, we've evolved to be smart enough to make ourselves… — Robert M. Sapolsky Copy Share Image
“Finally, for the same criminal conviction, the more stereotypically Af-rican a black individual’s facial features, the longer the sentence.15 In contrast, juries view black (but not white) male defendants more favorably if they’re wearing big, clunky glasses; some defense attorneys even exploit this “nerd defense” by accessorizing their clients with fake glasses, and prosecuting attorneys ask whether those dorky glasses… — Robert M. Sapolsky Copy Share
“So testosterone does subtle things to behavior. Nonetheless, this doesn’t tell us much because everything can be interpreted every which way. Testosterone increases anxiety—you feel threatened and become more reactively aggressive. Testosterone decreases anxiety—you feel cocky and overconfident, become more preemptively aggressive. Testosterone increases risk taking—“Hey, let’s gamble and invade.” Testosterone increases risk taking—“Hey, let’s gamble and make a peace… — Robert M. Sapolsky Copy Share
“pain makes aggressive people more aggressive, while doing the opposite to unaggressive individuals.” — Robert M. Sapolsky Copy Share Image
“Thus, for our purposes, genes aren’t about inevitability. Instead they’re about context-dependent tendencies, propensities, potentials, and vulnerabilities. All embedded in the fabric of the… — Robert M. Sapolsky Copy Share Image
“If we accept that there will always be sides, it’s a nontrivial to-do list item to always be on the side of angels. Distrust essentialism. Keep in mind that what seems like rationality is often just rationalization, playing catch-up with subterranean forces that we never suspect. Focus on the larger, shared goals. Practice perspective taking. Individuate, individuate, individuate. Recall the… — Robert M. Sapolsky Copy Share
“In other words, the more genomically complex the organism, the larger the percentage of the genome devoted to gene regulation by the environment.” — Robert M. Sapolsky Copy Share Image
“The subject of one experiment is a rat that receives mild electric shocks (roughly equivalent to the static shock you might get from scuffing your foot on a carpet). Over a series of these, the rat develops a prolonged stress-response: its heart rate and glucocorticoid secretion rate go up, for example. For convenience, we can express the long-term consequences by… — Robert M. Sapolsky Copy Share
“No brain region is an island, and the formation of circuits connecting far-flung brain regions is crucial—how else can the frontal cortex use its… — Robert M. Sapolsky Copy Share Image
“We process emotionally salient information more rapidly and automatically, but with less accuracy. Frontal function—working memory, impulse control, executive decision making, risk assessment, and task shifting—is impaired, and the frontal cortex has less control over the amygdala. And we become less empathic and prosocial. Reducing sustained stress is a win-win for us and those stuck around us.” — Robert M. Sapolsky Copy Share
“Most broadly, the PFC chooses between conflicting options—Coke or Pepsi; blurting out what you really think or restraining yourself; pulling the trigger or not. And often the conflict being resolved is between a decision heavily driven by cognition and one driven by emotions. Once it has decided, the PFC sends orders via projections to the rest of the frontal cortex,… — Robert M. Sapolsky Copy Share
