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The big bulk of the response to antidepressants is the…

“The big bulk of the response to antidepressants is the placebo response.” quote by Irving Kirsch
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“The big bulk of the response to antidepressants is the placebo response.”

Irving Kirsch

About This Quote

This interpretation was drafted with AI assistance. It is one reading of the quote, not the author's own explanation.

Most of the benefit from antidepressants comes from patients’ expectations rather than the drug itself.

In simple terms: Placebo effect accounts for much of antidepressant improvement.

Key Takeaway

Recognize the power of expectation in treatment.

Themes

medicine psychology expectation

Mood

thoughtful critical

Type

scientific clinical

When to use this quote

  • clinical prescribing
  • therapy sessions
  • patient education

Key Concepts

neuroscience clinical trials mind‑body interaction

Questions to Reflect On

  • How can clinicians harness expectancy without misleading patients?
  • What role should placebos play in future research?
A Different Perspective

Relying on placebos raises ethical concerns about deception.

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