““Hippocrates, the ancient Greek doctor, concluded in the fourth century B.C. that pathological anxiety was a straightforward biological and medical problem. “If you cut open the head [of a mentally ill individual],” Hippocrates wrote, “you will find the brain humid, full of sweat and smelling badly.” For Hippocrates, “body juices” were the cause of madness; a sudden flood of bile to the brain would produce anxiety.””