““Glutamate signaling works in a fancier way that is essential to learning.2 To simplify considerably, while dendritic spines typically contain only one type of receptor, those responsive to glutamate contain two. The first (the “non-NMDA”) works in a conventional way—for every little smidgen of glutamate binding to these receptors, a smidgen of sodium flows in, causing a smidgen of excitation. The second (the “NMDA”) works in a nonlinear, threshold manner. It is usually unresponsive to glutamate. It’s not until the non-NMDA has been stimulated over and over by a long train of glutamate release, allowing enough sodium to flow in, that this activates the NMDA receptor. It suddenly responds to all that glutamate, opening its channels, allowing an explosion of excitation.””
