““Our modern microscopes, scanners, and sensors have disabused us of most of the old fanciful notions about the brain’s function. But the brain’s strangely remote quality—the way it seems both part of us and apart from us—still influences our perceptions in subtle ways. We have a sense that our brain exists in a state of splendid isolation, that its fundamental nature is impervious to the vagaries of our day-to-day lives. While we know that our brain is an exquisitely sensitive monitor of experience, we want to believe that it lies beyond the influence of experience. We want to believe that the impressions our brain records as sensations and stores as memories leave no physical imprint on its own structure. To believe otherwise would, we feel, call into question the integrity of the self.””