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If we denote excitation as an end-effect by the sign plus…

“If we denote excitation as an end-effect by the sign plus (+), and inhibition as end-effect by the sign minus (-), such a reflex as the scratch-reflex can be termed a reflex of double-sign, for it develops excitatory end-effect and then inhibitory end-effect even during the duration of the…” quote by Charles Scott Sherrington
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“If we denote excitation as an end-effect by the sign plus (+), and inhibition as end-effect by the sign minus (-), such a reflex as the scratch-reflex can be termed a reflex of double-sign, for it develops excitatory end-effect and then inhibitory end-effect even during the duration of the exciting stimulus.”

Charles Scott Sherrington

About This Quote

This interpretation was drafted with AI assistance. It is one reading of the quote, not the author's own explanation.

The scratch reflex exemplifies a double‑sign response: an initial excitatory phase followed by an inhibitory phase, even while the stimulus persists.

In simple terms: Reflexes combine excitation and inhibition.

Key Takeaway

Neural responses can be biphasic within a single stimulus.

Themes

neuroscience physiology reflex biology

Mood

objective technical

Type

scientific educational

When to use this quote

  • medical education
  • neuroscience research
  • physiotherapy training
  • biology textbooks

Key Concepts

neural circuitry signal integration

Practical Applications

  • model reflex pathways with dual phases
  • apply concept to design responsive prosthetics

Questions to Reflect On

  • Why does the nervous system employ inhibitory phases during ongoing stimulation?
  • How might double‑sign reflexes influence motor control?
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