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- The advances of biology during the past 20 years have been breathtaking, particularly in cracking the mystery of heredity. Nevertheless, the greatest… — H. Bentley Glass
- The difficult problems in life always start off being simple. Great affairs always start off being small. — Laozi
- The art of research [is] the art of making difficult problems soluble by devising means of getting at them. — Peter Medawar
- One of the most difficult problems of our age is that leaders, and perhaps academics as well, cannot readily admit that things… — Donald Michael Kraig
- The reward for being a good problem solver is to be heaped with more and more difficult problems to solve — R. Buckminster Fuller
- The most difficult problems are naturally not involved in the search for forms for contemporary life. It is a question of working… — Alvar Aalto
- It is almost always wrong that the time isn't ripe to decide something. That is always said of difficult problems. — Chris Patten
- Experience hobbles progress and leads to abandonment of difficult problems; it encourages the initiated to walk on the shady side of the… — William James Mayo