“Unlike lytic phages, CTXφ can actively replicate within V. cholerae and generate progeny phages without killing its host cell. The process of phage induction for CTXφ is also different; it occurs without excision of the prophage from the host cell… — Michael G Cordingley Copy Share Image
“ERV envelope genes possess unique properties that make them suitable for use in forming the placenta: they are fusogenic proteins and they have immunosuppresive properties. Eutherian (placental) mammals distinguish themselves from nonplacental animals in the ability of the female to nurture the fertilized ovum and growing embryo within the body. The placenta is a transient tissue of embryonic origin whose… — Michael G Cordingley Copy Share
“It is also reasonable to speculate that the capacity of prophages to be induced at a low frequency must in itself be advantageous to the phage genome. It is attractive to think of this as a hedging strategy, in which the genetically identical phage population can simultaneously exploit two different phenotypes - in this case, to optimize its probability of… — Michael G Cordingley Copy Share
“In early primates, we can pinpoint a particular ERV integration event into the locus of the pancreatic amylase gene that conferred upon our ancestors the ability to express their amylase genes in the salivary gland. This heritable change provided for tissue-specific expression of the gene and gave us our sweet tooth. Here, the introduction of new gene regulatory DNA sequences… — Michael G Cordingley Copy Share
“Such then is the nature of quasispecies : the density of the sequence cloud at any point in sequence space is determined by the… — Michael G Cordingley Copy Share Image
“The litter of ERVs across vertebrate genomes, mainly in the form of defective and deleted proviruses, mutationally inactivated proteins coding sequences, and isolated LTRs,… — Michael G Cordingley Copy Share Image
“The results of the studies opened up a whole new avenue of research into live-attenuated vaccines: synthetic attenuated virus engineering (SAVE). A virus was… — Michael G Cordingley Copy Share Image
“Unlike lytic phages, CTXφ can actively replicate within V. cholerae and generate progeny phages without killing its host cell. The process of phage induction… — Michael G Cordingley Copy Share Image
“The researchers looked deeper into these observations, in hopes of gaining insight into the mechanisms underlying the high evolutionary rate and extraordinary immunologic plasticity… — Michael G Cordingley Copy Share Image
“The accelerating pace of zoonotic transmission of novel viruses into humans is attributable to anthropogenic epidemiologic factors. Only behavior modification or medical management of… — Michael G Cordingley Copy Share Image
“The basis for the potential of all virolytic therapeutics resides in the exquisite selectivity they exhibit for infecting and killing cancer cells. The very… — Michael G Cordingley Copy Share Image
“Vaccination with a live-attenuated virus vaccine can be compared with the cross-species transmission of viruses that cause zoonotic infection. If the vaccine strain is… — Michael G Cordingley Copy Share Image
“Collectively, the veritable zoo of mobile genetic elements comprises a remarkable 40 percent of our genome. The retroviral sequences littered across all vertebrate genomes… — Michael G Cordingley Copy Share Image
