“The results of the studies opened up a whole new avenue of research into live-attenuated vaccines: synthetic attenuated virus engineering (SAVE). A virus was created with 631 synonymous mutations in its P1 coding sequence, designed to bias it toward the… — Michael G Cordingley Copy Share Image
“Vaccination with a live-attenuated virus vaccine can be compared with the cross-species transmission of viruses that cause zoonotic infection. If the vaccine strain is an RNA virus, it can be expected that the vaccine inoculum will be made up of… — Michael G Cordingley Copy Share Image
“ERV envelope genes possess unique properties that make them suitable for use in forming the placenta: they are fusogenic proteins and they have immunosuppresive… — Michael G Cordingley Copy Share Image
“It is also reasonable to speculate that the capacity of prophages to be induced at a low frequency must in itself be advantageous to… — Michael G Cordingley Copy Share Image
“In early primates, we can pinpoint a particular ERV integration event into the locus of the pancreatic amylase gene that conferred upon our ancestors… — Michael G Cordingley Copy Share Image
“Such then is the nature of quasispecies : the density of the sequence cloud at any point in sequence space is determined by the… — Michael G Cordingley Copy Share Image
“The litter of ERVs across vertebrate genomes, mainly in the form of defective and deleted proviruses, mutationally inactivated proteins coding sequences, and isolated LTRs,… — Michael G Cordingley Copy Share Image
“The results of the studies opened up a whole new avenue of research into live-attenuated vaccines: synthetic attenuated virus engineering (SAVE). A virus was… — Michael G Cordingley Copy Share Image
“Unlike lytic phages, CTXφ can actively replicate within V. cholerae and generate progeny phages without killing its host cell. The process of phage induction… — Michael G Cordingley Copy Share Image
“The researchers looked deeper into these observations, in hopes of gaining insight into the mechanisms underlying the high evolutionary rate and extraordinary immunologic plasticity… — Michael G Cordingley Copy Share Image
“The accelerating pace of zoonotic transmission of novel viruses into humans is attributable to anthropogenic epidemiologic factors. Only behavior modification or medical management of… — Michael G Cordingley Copy Share Image
“The basis for the potential of all virolytic therapeutics resides in the exquisite selectivity they exhibit for infecting and killing cancer cells. The very… — Michael G Cordingley Copy Share Image
“Vaccination with a live-attenuated virus vaccine can be compared with the cross-species transmission of viruses that cause zoonotic infection. If the vaccine strain is… — Michael G Cordingley Copy Share Image
“Collectively, the veritable zoo of mobile genetic elements comprises a remarkable 40 percent of our genome. The retroviral sequences littered across all vertebrate genomes… — Michael G Cordingley Copy Share Image
