--- title: "Meaning & Key Takeaway of: With respect to the ZPA, what kind of…" description: "\"With respect to the ZPA, what kind of digit develops depends on how close the digit is to the source of Sonic hedgehog.\" — Neil Shubin" image: "https://sms4smile.com/quotes/i/8cf/neil-shubin-14335_evolution_with-respect-to-the-zpa-what-kind-of-dig_1684226.png" --- # With respect to the ZPA, what kind of digit develops… ![“With respect to the ZPA, what kind of digit develops depends on how close the digit is to the source of Sonic hedgehog.” quote by Neil Shubin](https://sms4smile.com/quotes/i/8cf/neil-shubin-14335_evolution_with-respect-to-the-zpa-what-kind-of-dig_1684226.png) [Download](https://sms4smile.com/quotes/i/8cf/neil-shubin-14335_evolution_with-respect-to-the-zpa-what-kind-of-dig_1684226.png) [Open image](https://sms4smile.com/quotes/i/8cf/neil-shubin-14335_evolution_with-respect-to-the-zpa-what-kind-of-dig_1684226.png) > “With respect to the ZPA, what kind of digit develops depends on how close the digit is to the source of Sonic hedgehog.” [Neil Shubin](https://sms4smile.com/quotes/author/neil-shubin/) ## About This Quote This interpretation was drafted with AI assistance. It is one reading of the quote, not the author's own explanation. The development of a digit is influenced by its proximity to the source of Sonic hedgehog signaling, affecting pattern formation. **In simple terms:** Digit formation depends on closeness to a signaling source. Key Takeaway Consider spatial gradients in developmental studies. Themes development biology signaling Mood analytical inquisitive Type scientific explanatory When to use this quote - embryology research - tissue engineering - regenerative medicine Key Concepts morphogenesis gradient fields cell fate Questions to Reflect On - How does distance affect cell differentiation? - What other factors modulate digit formation? A Different Perspective Signals may interact with other pathways, complicating outcomes. ★ ★ ★ ★ ★ No ratings yet [Close Digit](https://sms4smile.com/quotes/about/close-digit-989046/) [Develops Depends](https://sms4smile.com/quotes/about/develops-depends-989045/) [Digit Develops](https://sms4smile.com/quotes/about/digit-develops-989043/) [Evolution](https://sms4smile.com/quotes/about/evolution/) [Hedgehog](https://sms4smile.com/quotes/about/hedgehog/) [Hedgehogs](https://sms4smile.com/quotes/about/hedgehogs/) [Kind](https://sms4smile.com/quotes/about/kind/) [Respect](https://sms4smile.com/quotes/about/respect/) [Sonic Hedgehog](https://sms4smile.com/quotes/about/sonic-hedgehog-989044/) [Source](https://sms4smile.com/quotes/about/source/) [Technology](https://sms4smile.com/quotes/about/technology/) ## Related quotes > [When I went to college, I discovered the Sega console, and 'Sonic the Hedgehog' became very dear to me.](https://sms4smile.com/quotes/edgar-wright/when-i-went-to-college-i-discovered-the-sega-console-and-sonic-the/) [Edgar Wright](https://sms4smile.com/quotes/author/edgar-wright/) > [Sonic the hedgehog is a beautiful statement on capitalism. 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