--- title: "Meaning & Key Takeaway of: Vaccination with a live-attenuated virus…" description: "\"“Vaccination with a live-attenuated virus vaccine can be compared with the cross-species transmission of viruses that cause zoonotic infection. If the ..." image: "https://sms4smile.com/quotes/i/317/michael-g-cordingley-38351_vaccine_vaccination-with-a-live-attenuated-virus_2965822.jpg" --- # Vaccination with a live-attenuated virus vaccine can be… ![“Vaccination with a live-attenuated virus vaccine can be compared with the cross-species transmission of viruses that cause zoonotic infection. If the vaccine strain is an RNA virus, it can be expected that the vaccine inoculum will be made up of a population of genotypes representing the…” quote by Michael G Cordingley](https://sms4smile.com/quotes/i/317/michael-g-cordingley-38351_vaccine_vaccination-with-a-live-attenuated-virus_2965822.jpg) [Download](https://sms4smile.com/quotes/i/317/michael-g-cordingley-38351_vaccine_vaccination-with-a-live-attenuated-virus_2965822.jpg) [Open image](https://sms4smile.com/quotes/i/317/michael-g-cordingley-38351_vaccine_vaccination-with-a-live-attenuated-virus_2965822.jpg) > ““Vaccination with a live-attenuated virus vaccine can be compared with the cross-species transmission of viruses that cause zoonotic infection. If the vaccine strain is an RNA virus, it can be expected that the vaccine inoculum will be made up of a population of genotypes representing the quasispecies which is created during replication and amplification of the virus in host cells. Furthermore, virus replication in the vaccine recipient creates genetic diversity, providing an opportunity for reversion of the attenuated phenotype. This is a real but rarely realized disadvantage of live-attenuated virus vaccines.”” [Michael G Cordingley](https://sms4smile.com/quotes/author/michael-g-cordingley/) ## About This Quote This interpretation was drafted with AI assistance. It is one reading of the quote, not the author's own explanation. Live‑attenuated vaccines can revert to harmful forms because they replicate and mutate like natural viruses. **In simple terms:** These vaccines may become dangerous after use. Key Takeaway Monitor and limit replication in vaccine design. Themes vaccine safety viral genetics public health risk assessment Mood cautious analytical Type scientific policy When to use this quote - clinical trials - regulatory review - public health policy Key Concepts quasispecies reversion risk RNA virus dynamics Questions to Reflect On - What safeguards can reduce reversion risk? - How to weigh vaccine benefits against potential hazards? A Different Perspective Balancing benefits and risks is complex. ★ ★ ★ ★ ★ No ratings yet [Attenuated Phenotype](https://sms4smile.com/quotes/about/attenuated-phenotype-4540888/) [Attenuated Virus](https://sms4smile.com/quotes/about/attenuated-virus-564859/) [Replication Vaccine](https://sms4smile.com/quotes/about/replication-vaccine-4540889/) [Vaccine](https://sms4smile.com/quotes/about/vaccine/) [Vaccine Inoculum](https://sms4smile.com/quotes/about/vaccine-inoculum-4540890/) [Vaccine Strain](https://sms4smile.com/quotes/about/vaccine-strain-4540887/) [Virus](https://sms4smile.com/quotes/about/virus/) ## Related quotes > [“The results of the studies opened up a whole new avenue of research into live-attenuated vaccines: synthetic attenuated virus engineering (SAVE). 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So, when the Ebola virus disappears between outbreaks, it has to be…](https://sms4smile.com/quotes/david-quammen/viruses-have-to-live-somewhere-they-can-only-replicate-in-living/) [David Quammen](https://sms4smile.com/quotes/author/david-quammen/) > [The launch of phase 1 Ebola vaccine studies is a first step in developing a vaccine that could be licensed and used in the…](https://sms4smile.com/quotes/anonymous/the-launch-of-phase-1-ebola-vaccine-studies-is-a-first-step-in/) [Anonymous](https://sms4smile.com/quotes/author/anonymous/) > [The coronavirus has yet again exposed the strong contrast between President Trump - who is working ardently for the American people - and a…](https://sms4smile.com/quotes/kayleigh-mcenany/the-coronavirus-has-yet-again-exposed-the-strong-contrast-between/) [Kayleigh McEnany](https://sms4smile.com/quotes/author/kayleigh-mcenany/) ## More by Michael G Cordingley > [“ERV envelope genes possess unique properties that make them suitable for use in forming the placenta: they are fusogenic proteins and they have immunosuppresive…](https://sms4smile.com/quotes/michael-g-cordingley/erv-envelope-genes-possess-unique-properties-that-make-them-suitable/) [Michael G Cordingley](https://sms4smile.com/quotes/author/michael-g-cordingley/) > [“It is also reasonable to speculate that the capacity of prophages to be induced at a low frequency must in itself be advantageous to…](https://sms4smile.com/quotes/michael-g-cordingley/it-is-also-reasonable-to-speculate-that-the-capacity-of-prophages-to/) [Michael G Cordingley](https://sms4smile.com/quotes/author/michael-g-cordingley/) > [“In early primates, we can pinpoint a particular ERV integration event into the locus of the pancreatic amylase gene that conferred upon our ancestors…](https://sms4smile.com/quotes/michael-g-cordingley/in-early-primates-we-can-pinpoint-a-particular-erv-integration-event/) [Michael G Cordingley](https://sms4smile.com/quotes/author/michael-g-cordingley/) > [“Such then is the nature of quasispecies : the density of the sequence cloud at any point in sequence space is determined by the…](https://sms4smile.com/quotes/michael-g-cordingley/such-then-is-the-nature-of-quasispecies-the-density-of-the-sequence/) [Michael G Cordingley](https://sms4smile.com/quotes/author/michael-g-cordingley/) > [“The litter of ERVs across vertebrate genomes, mainly in the form of defective and deleted proviruses, mutationally inactivated proteins coding sequences, and isolated LTRs,…](https://sms4smile.com/quotes/michael-g-cordingley/the-litter-of-ervs-across-vertebrate-genomes-mainly-in-the-form-of/) [Michael G Cordingley](https://sms4smile.com/quotes/author/michael-g-cordingley/) > [“The results of the studies opened up a whole new avenue of research into live-attenuated vaccines: synthetic attenuated virus engineering (SAVE). 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The retroviral sequences littered across all vertebrate genomes…](https://sms4smile.com/quotes/michael-g-cordingley/collectively-the-veritable-zoo-of-mobile-genetic-elements-comprises-a/) [Michael G Cordingley](https://sms4smile.com/quotes/author/michael-g-cordingley/) [Explore all 12 Michael G Cordingley quotes ](https://sms4smile.com/quotes/author/michael-g-cordingley/) ## More Vaccine quotes > [If you give us a safe vaccine, we'll use it. 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We have to immunise our children unless we are upset about it. 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Doherty](https://sms4smile.com/quotes/author/peter-c-doherty/) > [“At the time, though, vaccination was controversial. Many were opposed.”](https://sms4smile.com/quotes/jennifer-wright/at-the-time-though-vaccination-was-controversial-many-were-opposed/) [Jennifer Wright](https://sms4smile.com/quotes/author/jennifer-wright/) > [Reply when questioned on the safety of the polio vaccine he developed: It is safe, and you can't get safer than safe.](https://sms4smile.com/quotes/jonas-salk/reply-when-questioned-on-the-safety-of-the-polio-vaccine-he-developed/) [Jonas Salk](https://sms4smile.com/quotes/author/jonas-salk/) > [Vaccines have played a fundamental role in eradicating terrible illnesses such as polio, diphtheria, and hepatitis. 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It should be illegal for doctors to accept bonuses or other incentives from insurance…](https://sms4smile.com/quotes/stephen-heartland/solution-1-eliminate-payoffs-in-clinics-to-promote-vaccinations-it/) [stephen heartland](https://sms4smile.com/quotes/author/stephen-heartland/) > [I've never seen this level of anger at parents who've chosen not to vaccinate their children.](https://sms4smile.com/quotes/paul-a-offit/i-ve-never-seen-this-level-of-anger-at-parents-who-ve-chosen-not-to/) [Paul A. Offit](https://sms4smile.com/quotes/author/paul-a-offit/) [Browse all 250 Vaccine quotes ](https://sms4smile.com/quotes/about/vaccine/) ```json { "@context": "https://schema.org", "@graph": [ { "@type": "Quotation", "text": "“Vaccination with a live-attenuated virus vaccine can be compared with the cross-species transmission of viruses that cause zoonotic infection. 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