--- title: "Meaning & Key Takeaway of: In addition to single-gene genetic…" description: "\"“In addition to single-gene genetic disorders, there are just five causes of all disease: poor diet, chronic stress, microbes, toxins, and allergens, a..." image: "https://sms4smile.com/quotes/i/439/mark-hyman-22258_evolution_in-addition-to-single-gene-genetic-disor_3042103.jpg" --- # In addition to single-gene genetic disorders, there are… ![“In addition to single-gene genetic disorders, there are just five causes of all disease: poor diet, chronic stress, microbes, toxins, and allergens, all of which wash over our DNA causing changes in our gene expression, and turning off or on different genes and messages that affect our metabolism.” quote by Mark Hyman](https://sms4smile.com/quotes/i/439/mark-hyman-22258_evolution_in-addition-to-single-gene-genetic-disor_3042103.jpg) [Download](https://sms4smile.com/quotes/i/439/mark-hyman-22258_evolution_in-addition-to-single-gene-genetic-disor_3042103.jpg) [Open image](https://sms4smile.com/quotes/i/439/mark-hyman-22258_evolution_in-addition-to-single-gene-genetic-disor_3042103.jpg) > ““In addition to single-gene genetic disorders, there are just five causes of all disease: poor diet, chronic stress, microbes, toxins, and allergens, all of which wash over our DNA causing changes in our gene expression, and turning off or on different genes and messages that affect our metabolism.”” [Mark Hyman](https://sms4smile.com/quotes/author/mark-hyman/) ## About This Quote This interpretation was drafted with AI assistance. It is one reading of the quote, not the author's own explanation. Health is largely shaped by lifestyle factors that influence gene expression, not just genetics. **In simple terms:** Lifestyle choices affect our genes and health. Key Takeaway Focus on diet, stress, environment for health. Themes nutrition epigenetics wellness Mood informative concerned Type educational inspirational When to use this quote - diet planning - stress management - detoxification - allergy awareness Key Concepts gene expression environmental impact Questions to Reflect On - How can you modify daily habits for better health? - What environmental factors affect you most? A Different Perspective Genetics still play a role. ★ ★ ★ ★ ★ No ratings yet [Evolution](https://sms4smile.com/quotes/about/evolution/) ## Related quotes > [Heritability pertains to the entirety of the genome, not to a single gene.](https://sms4smile.com/quotes/steven-pinker/heritability-pertains-to-the-entirety-of-the-genome-not-to-a-single/) [Steven Pinker](https://sms4smile.com/quotes/author/steven-pinker/) > [We now know 600 different genes involved in cancer - giving rise to new drug targets.](https://sms4smile.com/quotes/eric-lander/we-now-know-600-different-genes-involved-in-cancer-giving-rise-to-new/) Eric Lander > [I am an Ashkenazi Jew, and there are a whole host of genetic disorders that only Ashkenazi Jews have. I don't know if you…](https://sms4smile.com/quotes/james-gray/i-am-an-ashkenazi-jew-and-there-are-a-whole-host-of-genetic-disorders/) [James Gray](https://sms4smile.com/quotes/author/james-gray/) > [The American diet causes disease. It is composed of 25 percent animal products and 62 percent processed foods and only 5 percent of calories…](https://sms4smile.com/quotes/joel-fuhrman/the-american-diet-causes-disease-it-is-composed-of-25-percent-animal/) [Joel Fuhrman](https://sms4smile.com/quotes/author/joel-fuhrman/) > [What causes autism? As far as we know in 2013, there is no single gene or single environmental factor that accounts for the more…](https://sms4smile.com/quotes/thomas-r-insel/what-causes-autism-as-far-as-we-know-in-2013-there-is-no-single-gene/) [Thomas R. Insel](https://sms4smile.com/quotes/author/thomas-r-insel/) > [“Sex, one of the most complex of human traits, is unlikely to be encoded by multiple genes. Rather, a single gene, buried rather precariously…](https://sms4smile.com/quotes/siddhartha-mukherjee/sex-one-of-the-most-complex-of-human-traits-is-unlikely-to-be-encoded/) [Siddhartha Mukherjee](https://sms4smile.com/quotes/author/siddhartha-mukherjee/) > [The origin and the causes of disease are far too recondite for the human mind to unravel them.](https://sms4smile.com/quotes/giorgio-baglivi/the-origin-and-the-causes-of-disease-are-far-too-recondite-for-the/) Giorgio Baglivi > [“The candidate gene approaches show that the effect of a single gene on a behavior is typically tiny. In other words, having the “warrior…](https://sms4smile.com/quotes/robert-m-sapolsky/the-candidate-gene-approaches-show-that-the-effect-of-a-single-gene/) [Robert M. Sapolsky](https://sms4smile.com/quotes/author/robert-m-sapolsky/) > [“the shorter your sleep, the shorter your life. The leading causes of disease and death in developed nations—diseases that are crippling health-care systems, such…](https://sms4smile.com/quotes/matthew-walker/the-shorter-your-sleep-the-shorter-your-life-the-leading-causes-of/) [Matthew Walker](https://sms4smile.com/quotes/author/matthew-walker/) > [With the modern diseases (once TB, now cancer) the romantic idea that the disease expresses the character is invariably extended to assert that the…](https://sms4smile.com/quotes/susan-sontag/with-the-modern-diseases-once-tb-now-cancer-the-romantic-idea-that/) [Susan Sontag](https://sms4smile.com/quotes/author/susan-sontag/) > [“Genetics is a science full of gods, Mr. Sanchez.”](https://sms4smile.com/quotes/valeria-luiselli/genetics-is-a-science-full-of-gods-mr-sanchez/) [Valeria Luiselli](https://sms4smile.com/quotes/author/valeria-luiselli/) > [If the polymer chain assumes a helicoidal conformation in the crystalline state, and if it does not contain asymmetric carbon atoms, it can be…](https://sms4smile.com/quotes/giulio-natta/if-the-polymer-chain-assumes-a-helicoidal-conformation-in-the/) Giulio Natta > [“A question for Christians who accept evolution: When did we gain a "soul"? Did Homo habilis have a soul? Homo ergaster? Did God only…](https://sms4smile.com/quotes/david-g-mcafee/a-question-for-christians-who-accept-evolution-when-did-we-gain-a/) [David G. McAfee](https://sms4smile.com/quotes/author/david-g-mcafee/) > [At the deepest level, all living things that have ever been looked at have the same DNA code. And many of the same genes.](https://sms4smile.com/quotes/richard-dawkins/at-the-deepest-level-all-living-things-that-have-ever-been-looked-at/) [Richard Dawkins](https://sms4smile.com/quotes/author/richard-dawkins/) > [I rap when I'm rich. I rap when I'm broke. I rap when I'm bullshit in the street. I rap about only having one…](https://sms4smile.com/quotes/killer-mike/i-rap-when-i-m-rich-i-rap-when-i-m-broke-i-rap-when-i-m-bullshit-in/) [Killer Mike](https://sms4smile.com/quotes/author/killer-mike/) ## More by Mark Hyman > [“How we eat, how much we exercise, how we manage stress, our exposure to environmental and food-based toxins, and the structural violence or “obesogenic…](https://sms4smile.com/quotes/mark-hyman/how-we-eat-how-much-we-exercise-how-we-manage-stress-our-exposure-to/) [Mark Hyman](https://sms4smile.com/quotes/author/mark-hyman/) > [“My advice is to give up stevia, aspartame, sucralose, sugar alcohols such as xylitol and malitol, and all of the other heavily used and…](https://sms4smile.com/quotes/mark-hyman/my-advice-is-to-give-up-stevia-aspartame-sucralose-sugar-alcohols/) [Mark Hyman](https://sms4smile.com/quotes/author/mark-hyman/) > [“We know that food is a medicine, perhaps the most powerful drug on the planet with the power to cause or cure most diseases.”](https://sms4smile.com/quotes/mark-hyman/we-know-that-food-is-a-medicine-perhaps-the-most-powerful-drug-on-the/) [Mark Hyman](https://sms4smile.com/quotes/author/mark-hyman/) > [“The way modern medicine operates is like trying to diagnose what’s wrong with your car by listening to the noises it makes instead of…](https://sms4smile.com/quotes/mark-hyman/the-way-modern-medicine-operates-is-like-trying-to-diagnose-what-s/) [Mark Hyman](https://sms4smile.com/quotes/author/mark-hyman/) > [“This starts with personal action and community organization. Creating a healthier world is a revolutionary act, one you can start right now.”](https://sms4smile.com/quotes/mark-hyman/this-starts-with-personal-action-and-community-organization-creating/) [Mark Hyman](https://sms4smile.com/quotes/author/mark-hyman/) > [While pimples are not as simple as too much milk or sugar in your diet, both have a significant impact. Nutritional deficiencies as well…](https://sms4smile.com/quotes/mark-hyman/while-pimples-are-not-as-simple-as-too-much-milk-or-sugar-in-your/) [Mark Hyman](https://sms4smile.com/quotes/author/mark-hyman/) > [“Negative lifestyle choices and high job stress led me down a path of alcohol and nicotine abuse, and eventually open heart surgery.”](https://sms4smile.com/quotes/mark-hyman/negative-lifestyle-choices-and-high-job-stress-led-me-down-a-path-of/) [Mark Hyman](https://sms4smile.com/quotes/author/mark-hyman/) > [Today there are not even enough fruits and vegetables in this country to allow all Americans to follow the government guidelines to eat five…](https://sms4smile.com/quotes/mark-hyman/today-there-are-not-even-enough-fruits-and-vegetables-in-this-country/) [Mark Hyman](https://sms4smile.com/quotes/author/mark-hyman/) > [“First, when you try to restrict calories and exercise more, your body is hardwired to perceive a starvation situation. That makes you tired (so…](https://sms4smile.com/quotes/mark-hyman/first-when-you-try-to-restrict-calories-and-exercise-more-your-body/) [Mark Hyman](https://sms4smile.com/quotes/author/mark-hyman/) > [“control, and even cure muscle cramps.”](https://sms4smile.com/quotes/mark-hyman/control-and-even-cure-muscle-cramps/) [Mark Hyman](https://sms4smile.com/quotes/author/mark-hyman/) > [The food industry profits from providing poor quality foods with poor nutritional value that people eat a lot of.](https://sms4smile.com/quotes/mark-hyman/the-food-industry-profits-from-providing-poor-quality-foods-with-poor/) [Mark Hyman](https://sms4smile.com/quotes/author/mark-hyman/) > [Through my work and travels I have been lucky enough to have been exposed to various eclectic cuisine running the gamut from small local…](https://sms4smile.com/quotes/mark-hyman/through-my-work-and-travels-i-have-been-lucky-enough-to-have-been/) [Mark Hyman](https://sms4smile.com/quotes/author/mark-hyman/) > [We have to pay close attention to what we see, and be ready to work with the unexpected according to the basic principles of…](https://sms4smile.com/quotes/mark-hyman/we-have-to-pay-close-attention-to-what-we-see-and-be-ready-to-work/) [Mark Hyman](https://sms4smile.com/quotes/author/mark-hyman/) > [Placing too much emphasis on a yes/no diagnosis, meaning you either have a disease or you don't, can lead even the most well-meaning physicians…](https://sms4smile.com/quotes/mark-hyman/placing-too-much-emphasis-on-a-yes-no-diagnosis-meaning-you-either/) [Mark Hyman](https://sms4smile.com/quotes/author/mark-hyman/) > [Paradoxically Americans are becoming both more obese and more nutrient deficient at the same time. Obese children eating processed foods are nutrient depleted and…](https://sms4smile.com/quotes/mark-hyman/paradoxically-americans-are-becoming-both-more-obese-and-more/) [Mark Hyman](https://sms4smile.com/quotes/author/mark-hyman/) [Explore all 27 Mark Hyman quotes ](https://sms4smile.com/quotes/author/mark-hyman/) ## More Evolution quotes > [I rap when I'm rich. I rap when I'm broke. I rap when I'm bullshit in the street. I rap about only having one…](https://sms4smile.com/quotes/killer-mike/i-rap-when-i-m-rich-i-rap-when-i-m-broke-i-rap-when-i-m-bullshit-in/) [Killer Mike](https://sms4smile.com/quotes/author/killer-mike/) > [At the deepest level, all living things that have ever been looked at have the same DNA code. And many of the same genes.](https://sms4smile.com/quotes/richard-dawkins/at-the-deepest-level-all-living-things-that-have-ever-been-looked-at/) [Richard Dawkins](https://sms4smile.com/quotes/author/richard-dawkins/) > [“A question for Christians who accept evolution: When did we gain a "soul"? Did Homo habilis have a soul? Homo ergaster? Did God only…](https://sms4smile.com/quotes/david-g-mcafee/a-question-for-christians-who-accept-evolution-when-did-we-gain-a/) [David G. McAfee](https://sms4smile.com/quotes/author/david-g-mcafee/) > [If the polymer chain assumes a helicoidal conformation in the crystalline state, and if it does not contain asymmetric carbon atoms, it can be…](https://sms4smile.com/quotes/giulio-natta/if-the-polymer-chain-assumes-a-helicoidal-conformation-in-the/) Giulio Natta > [“Genetics is a science full of gods, Mr. Sanchez.”](https://sms4smile.com/quotes/valeria-luiselli/genetics-is-a-science-full-of-gods-mr-sanchez/) [Valeria Luiselli](https://sms4smile.com/quotes/author/valeria-luiselli/) > [We became Homo sapiens not that long ago, from the scientific perspective, and we've retained a lot of our beast nature. We've done all…](https://sms4smile.com/quotes/wangechi-mutu/we-became-homo-sapiens-not-that-long-ago-from-the-scientific/) [Wangechi Mutu](https://sms4smile.com/quotes/author/wangechi-mutu/) > [Guns have little or nothing to do with juvenile violence. The causes of youth violence are working parents who put their kids into daycare,…](https://sms4smile.com/quotes/tom-delay/guns-have-little-or-nothing-to-do-with-juvenile-violence-the-causes/) [Tom DeLay](https://sms4smile.com/quotes/author/tom-delay/) > [The fact -- not theory -- that evolution has occurred and the Darwinian theory as to how it occurred have become so confused in…](https://sms4smile.com/quotes/george-gaylord-simpson/the-fact-not-theory-that-evolution-has-occurred-and-the-darwinian/) [George Gaylord Simpson](https://sms4smile.com/quotes/author/george-gaylord-simpson/) > [Perhaps no order of mammals presents us with so extraordinary a series of gradations as this \[step by step, from humans to apes to…](https://sms4smile.com/quotes/thomas-huxley/perhaps-no-order-of-mammals-presents-us-with-so-extraordinary-a/) [Thomas Huxley](https://sms4smile.com/quotes/author/thomas-huxley/) > [Evolution happens in jumps, very rapidly.](https://sms4smile.com/quotes/marilyn-ferguson/evolution-happens-in-jumps-very-rapidly/) [Marilyn Ferguson](https://sms4smile.com/quotes/author/marilyn-ferguson/) > [The true nature of soul is right knowledge, right faith and right conduct. The soul, so long as it is subject to transmigration, is…](https://sms4smile.com/quotes/virchand-gandhi/the-true-nature-of-soul-is-right-knowledge-right-faith-and-right/) [Virchand Gandhi](https://sms4smile.com/quotes/author/virchand-gandhi/) > [“Toshiaki learned that all living organisms were governed by their DNA. He was impressed by perfection of this system.Why did existence have the ability…](https://sms4smile.com/quotes/hideaki-sena/toshiaki-learned-that-all-living-organisms-were-governed-by-their-dna/) Hideaki Sena > [The shelves of many evangelicals are full of books that point out the flaws in evolution, discuss it only as a theory, and almost…](https://sms4smile.com/quotes/francis-collins/the-shelves-of-many-evangelicals-are-full-of-books-that-point-out-the/) [Francis Collins](https://sms4smile.com/quotes/author/francis-collins/) > [I'm all about evolution. I'm the first person to judge myself.](https://sms4smile.com/quotes/the-weeknd/i-m-all-about-evolution-i-m-the-first-person-to-judge-myself/) [The Weeknd](https://sms4smile.com/quotes/author/the-weeknd/) > [The next evolution of content marketing is not more content; it's better distribution.](https://sms4smile.com/quotes/chris-penn/the-next-evolution-of-content-marketing-is-not-more-content-it-s/) [Chris Penn](https://sms4smile.com/quotes/author/chris-penn/) [Browse all 6,185 Evolution quotes ](https://sms4smile.com/quotes/about/evolution/) ```json { "@context": "https://schema.org", "@graph": [ { "@type": "Quotation", "text": "“In addition to single-gene genetic disorders, there are just five causes of all disease: poor diet, chronic stress, microbes, toxins, and allergens, all of which wash over our DNA causing changes in our gene expression, and turning off or on different genes and messages that affect our metabolism.”", "creator": { "@type": "Person", "name": "Mark Hyman" }, "isPartOf": { "@id": "https://sms4smile.com/quotes/#website" }, "url": "https://sms4smile.com/quotes/mark-hyman/in-addition-to-single-gene-genetic-disorders-there-are-just-five/", "about": { "@type": "Thing", "name": "Evolution" }, "@id": "https://sms4smile.com/quotes/mark-hyman/in-addition-to-single-gene-genetic-disorders-there-are-just-five/#quotation", "image": { "@type": "ImageObject", "@id": "https://sms4smile.com/quotes/i/439/mark-hyman-22258_evolution_in-addition-to-single-gene-genetic-disor_3042103.jpg", "contentUrl": "https://sms4smile.com/quotes/i/439/mark-hyman-22258_evolution_in-addition-to-single-gene-genetic-disor_3042103.jpg", "url": "https://sms4smile.com/quotes/i/439/mark-hyman-22258_evolution_in-addition-to-single-gene-genetic-disor_3042103.jpg", "width": 1080, "height": 1080, "caption": "“In addition to single-gene genetic disorders, there are just five causes of all disease: poor diet, chronic…” — Mark Hyman", "creditText": "SMS4Smile Quotes", "creator": { "@id": "https://sms4smile.com/quotes/#organization" } } }, { "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://sms4smile.com/" }, { "@type": "ListItem", "position": 2, "name": "Quotes", "item": "https://sms4smile.com/quotes/" }, { "@type": "ListItem", "position": 3, "name": "Mark Hyman", "item": "https://sms4smile.com/quotes/author/mark-hyman/" }, { "@type": "ListItem", "position": 4, "name": "“In addition to single-gene genetic disorders,...", "item": "https://sms4smile.com/quotes/mark-hyman/in-addition-to-single-gene-genetic-disorders-there-are-just-five/" } ], "@id": "https://sms4smile.com/quotes/mark-hyman/in-addition-to-single-gene-genetic-disorders-there-are-just-five/#breadcrumb" }, { "@type": "WebSite", "@id": "https://sms4smile.com/quotes/#website", "name": "SMS4Smile Quotes", "url": "https://sms4smile.com/quotes/", "publisher": { "@id": "https://sms4smile.com/quotes/#organization" } }, { "@type": "Organization", "@id": "https://sms4smile.com/quotes/#organization", "name": "SMS4Smile Quotes", "url": "https://sms4smile.com/quotes/", "logo": { "@type": "ImageObject", "url": "https://sms4smile.com/quotes/wp-content/themes/sq/assets/icons/icon-512.png", "width": 512, "height": 512 } } ] } ```