--- title: "Meaning & Key Takeaway of: It would be great if you could cool the…" description: "\"It would be great if you could cool the water and immobilise the molecules, though keeping the structure, because when it's frozen, when it's immobilis..." image: "https://sms4smile.com/quotes/i/22f/jacques-dubochet-41031_cool_it-would-be-great-if-you-could-cool-the_1115529.jpg" --- # It would be great if you could cool the water and… ![“It would be great if you could cool the water and immobilise the molecules, though keeping the structure, because when it's frozen, when it's immobilised, you can have it in the electron microscope and the water will not evaporate because in the electron microscope, it must be under vacuum, and…” quote by Jacques Dubochet](https://sms4smile.com/quotes/i/22f/jacques-dubochet-41031_cool_it-would-be-great-if-you-could-cool-the_1115529.jpg) [Download](https://sms4smile.com/quotes/i/22f/jacques-dubochet-41031_cool_it-would-be-great-if-you-could-cool-the_1115529.jpg) [Open image](https://sms4smile.com/quotes/i/22f/jacques-dubochet-41031_cool_it-would-be-great-if-you-could-cool-the_1115529.jpg) > “It would be great if you could cool the water and immobilise the molecules, though keeping the structure, because when it's frozen, when it's immobilised, you can have it in the electron microscope and the water will not evaporate because in the electron microscope, it must be under vacuum, and water at normal temperature evaporates.” [Jacques Dubochet](https://sms4smile.com/quotes/author/jacques-dubochet/) ## About This Quote This interpretation was drafted with AI assistance. It is one reading of the quote, not the author's own explanation. Cooling water while preserving its structure enables electron microscopy without evaporation. **In simple terms:** Freeze water to view it under a microscope. Key Takeaway Preserve samples by rapid freezing. Themes science technology microscopy Mood technical curious Type explanatory informative When to use this quote - biological imaging - structural biology - nanotechnology - materials science Key Concepts Cryogenics electron microscopy sample preservation Questions to Reflect On - What samples benefit most from cryo‑EM? - How does freezing affect molecular integrity? A Different Perspective Freezing may alter delicate structures; not all samples survive. ★ ★ ★ ★ ★ No ratings yet [Cool](https://sms4smile.com/quotes/about/cool/) [Cool water](https://sms4smile.com/quotes/about/cool-water/) [Evaporate Electron](https://sms4smile.com/quotes/about/evaporate-electron-2994123/) [Frozen Immobilised](https://sms4smile.com/quotes/about/frozen-immobilised-2994125/) [Great](https://sms4smile.com/quotes/about/great/) [Immobilise Molecules](https://sms4smile.com/quotes/about/immobilise-molecules-2994124/) [Normal](https://sms4smile.com/quotes/about/normal/) [Water](https://sms4smile.com/quotes/about/water/) [Water Immobilise](https://sms4smile.com/quotes/about/water-immobilise-2994126/) [Will](https://sms4smile.com/quotes/about/will/) ## Related quotes > [You will find a spring by the dwelling of the dead, to the left. Next to it stands a white cypress. 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By...doses of...medicines...multiplying...combining them properly, 20 to 30 articles, aided by the common resources of…](https://sms4smile.com/quotes/benjamin-rush/this-large-and-expensive-stock-of-drugs-will-be-unnecessary-by-doses/) [Benjamin Rush](https://sms4smile.com/quotes/author/benjamin-rush/) > [Kawasan Falls in Badian, Cebu Philippines : kawasan falls Cebu is a peaceful natural place where you can enjoy many waterfalls of natural spring…](https://sms4smile.com/quotes/zhat/kawasan-falls-in-badian-cebu-philippines-kawasan-falls-cebu-is-a/) [Zhat](https://sms4smile.com/quotes/author/zhat/) > [I gave my heart to the mountains the minute I stood beside this river with its spray in my face and watched it thunder…](https://sms4smile.com/quotes/wallace-stegner/i-gave-my-heart-to-the-mountains-the-minute-i-stood-beside-this-river/) [Wallace Stegner](https://sms4smile.com/quotes/author/wallace-stegner/) > [“Do you know what happens, Etienne,” says Madame Manec from the other side of the kitchen, “when you drop a frog in a pot…](https://sms4smile.com/quotes/anthony-doerr/do-you-know-what-happens-etienne-says-madame-manec-from-the-other/) [Anthony Doerr](https://sms4smile.com/quotes/author/anthony-doerr/) > [“To fall in love is like taking that first plunge into the cool water. Once you are in the water and wet, the pool…](https://sms4smile.com/quotes/alysonserenastone-give-your-a-break/to-fall-in-love-is-like-taking-that-first-plunge-into-the-cool-water/) [AlysonSerenaStone Give Your A Break](https://sms4smile.com/quotes/author/alysonserenastone-give-your-a-break/) ## More by Jacques Dubochet > [In our group, it was a necessary requirement that one has to be able to collaborate.](https://sms4smile.com/quotes/jacques-dubochet/in-our-group-it-was-a-necessary-requirement-that-one-has-to-be-able/) [Jacques Dubochet](https://sms4smile.com/quotes/author/jacques-dubochet/) > [A scientific prize is an ambiguous thing: it highlights an individual when we should highlight a collective effort, but I'm not alone.](https://sms4smile.com/quotes/jacques-dubochet/a-scientific-prize-is-an-ambiguous-thing-it-highlights-an-individual/) [Jacques Dubochet](https://sms4smile.com/quotes/author/jacques-dubochet/) > [We three have never been very good chemists but we are gratified with a Nobel Prize in Chemistry. 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Really Cool.](https://sms4smile.com/quotes/serivce/vo5c0y-muchos-gracias-for-your-article-really-looking-forward-to-read/) [Serivce](https://sms4smile.com/quotes/author/serivce/) > [What a cool job to be part of - whether it's doing lighting or acting or serving food on set. You're part of telling…](https://sms4smile.com/quotes/laura-dern/what-a-cool-job-to-be-part-of-whether-it-s-doing-lighting-or-acting/) [Laura Dern](https://sms4smile.com/quotes/author/laura-dern/) > [Jail is definitely not cool. 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