--- title: "Meaning & Key Takeaway of: The bottom line is that if you want to…" description: "\"“The bottom line is that if you want to reduce oxidative stress and the action of free radicals harming your brain, you have to reduce the glycation of..." image: "https://sms4smile.com/quotes/i/b3b/david-perlmutter-2461_bottom-line_the-bottom-line-is-that-if-you-want-to-r_1380907.png" --- # The bottom line is that if you want to reduce oxidative… ![“The bottom line is that if you want to reduce oxidative stress and the action of free radicals harming your brain, you have to reduce the glycation of proteins. Which is to say, you have to diminish the availability of sugar. Pure and simple.” quote by David Perlmutter](https://sms4smile.com/quotes/i/b3b/david-perlmutter-2461_bottom-line_the-bottom-line-is-that-if-you-want-to-r_1380907.png) [Download](https://sms4smile.com/quotes/i/b3b/david-perlmutter-2461_bottom-line_the-bottom-line-is-that-if-you-want-to-r_1380907.png) [Open image](https://sms4smile.com/quotes/i/b3b/david-perlmutter-2461_bottom-line_the-bottom-line-is-that-if-you-want-to-r_1380907.png) > ““The bottom line is that if you want to reduce oxidative stress and the action of free radicals harming your brain, you have to reduce the glycation of proteins. Which is to say, you have to diminish the availability of sugar. Pure and simple.”” [David Perlmutter](https://sms4smile.com/quotes/author/david-perlmutter/) ## About This Quote This interpretation was drafted with AI assistance. It is one reading of the quote, not the author's own explanation. Reducing sugar intake lowers protein glycation, which in turn diminishes oxidative stress and protects brain health from free radical damage. **In simple terms:** Less sugar means less brain damage from free radicals. Key Takeaway Cut down sugar to protect your brain. Themes nutrition brain health oxidative stress glycation free radicals Mood concerned motivated informative Type practical educational When to use this quote - daily meal planning - patient counseling - public health campaigns - research studies - personal health tracking Key Concepts dietary impact metabolic health preventive medicine Questions to Reflect On - What are practical ways to lower sugar intake? - How does glycation affect other organs? A Different Perspective Sugar reduction alone may not address all oxidative stress sources. ★ ★ ★ ★ ★ No ratings yet [Bottom line](https://sms4smile.com/quotes/about/bottom-line/) [Food](https://sms4smile.com/quotes/about/food/) [Free Radicals](https://sms4smile.com/quotes/about/free-radicals-275143/) [Glycation Proteins](https://sms4smile.com/quotes/about/glycation-proteins-4783213/) [Oxidative Stress](https://sms4smile.com/quotes/about/oxidative-stress-3218123/) [Reduce Glycation](https://sms4smile.com/quotes/about/reduce-glycation-2579146/) [Reduce Oxidative](https://sms4smile.com/quotes/about/reduce-oxidative-4783212/) ## Related quotes > [“Exercise also improves insulin sensitivity. It helps manage blood sugar balance and reduce the glycation of proteins.”](https://sms4smile.com/quotes/david-perlmutter/exercise-also-improves-insulin-sensitivity-it-helps-manage-blood/) [David Perlmutter](https://sms4smile.com/quotes/author/david-perlmutter/) > [Activating oxygen can produce compounds called radicals that put oxidative stress on cells. Such stress could ultimately lead to cancer and other diseases.](https://sms4smile.com/quotes/john-simon/activating-oxygen-can-produce-compounds-called-radicals-that-put/) [John Simon](https://sms4smile.com/quotes/author/john-simon/) > [“In particular, raising blood sugar will increase the production of what are known technically as reactive oxygen species and advanced glycation end-products, both of…](https://sms4smile.com/quotes/gary-taubes/in-particular-raising-blood-sugar-will-increase-the-production-of/) [Gary Taubes](https://sms4smile.com/quotes/author/gary-taubes/) > [“how effective would, say, a vitamin E capsule or a tablet of vitamin C be when confronted by this onslaught of free radicals? Common”](https://sms4smile.com/quotes/david-perlmutter/how-effective-would-say-a-vitamin-e-capsule-or-a-tablet-of-vitamin-c/) [David Perlmutter](https://sms4smile.com/quotes/author/david-perlmutter/) > [Antioxidants are chemicals that break down or neutralize the damaging effects of free radicals - chemicals produced as a byproduct of normal cellular metabolism.](https://sms4smile.com/quotes/david-perlmutter/antioxidants-are-chemicals-that-break-down-or-neutralize-the-damaging/) [David Perlmutter](https://sms4smile.com/quotes/author/david-perlmutter/) > [“people with celiac have significantly increased production of free radicals, and they exhibit free radical damage to their fat, protein, and even DNA.16 In…](https://sms4smile.com/quotes/david-perlmutter/people-with-celiac-have-significantly-increased-production-of-free/) [David Perlmutter](https://sms4smile.com/quotes/author/david-perlmutter/) > [“one molecule of vitamin C is oxidized by one free radical. (This one-to-one chemistry is called a stoichiometric reaction by chemists.) Can you imagine…](https://sms4smile.com/quotes/david-perlmutter/one-molecule-of-vitamin-c-is-oxidized-by-one-free-radical-this-one-to/) [David Perlmutter](https://sms4smile.com/quotes/author/david-perlmutter/) > [The human brain is at particularly high risk for damage by free radicals because of its high degree of metabolism compared to other tissues,…](https://sms4smile.com/quotes/david-perlmutter/the-human-brain-is-at-particularly-high-risk-for-damage-by-free/) [David Perlmutter](https://sms4smile.com/quotes/author/david-perlmutter/) > [Gotta get rid of these free radicals, but first I need to figure out what they are.](https://sms4smile.com/quotes/dov-davidoff/gotta-get-rid-of-these-free-radicals-but-first-i-need-to-figure-out/) [Dov Davidoff](https://sms4smile.com/quotes/author/dov-davidoff/) > [Vanilla is anti-inflammatory and reduces free radicals.](https://sms4smile.com/quotes/hannah-bronfman/vanilla-is-anti-inflammatory-and-reduces-free-radicals/) [Hannah Bronfman](https://sms4smile.com/quotes/author/hannah-bronfman/) > [“Jesus is the antioxidant that terminates all the free radicals (sin) in our lives. Consume more of Jesus and watch your overall health rise!”](https://sms4smile.com/quotes/alisa-hope-wagner/jesus-is-the-antioxidant-that-terminates-all-the-free-radicals-sin-in/) [Alisa Hope Wagner](https://sms4smile.com/quotes/author/alisa-hope-wagner/) > [“So how does the plant manage these complex reactions and protect against errant electrons and free radicals? It puts up a shield around potentially…](https://sms4smile.com/quotes/t-colin-campbell/so-how-does-the-plant-manage-these-complex-reactions-and-protect/) [T. Colin Campbell](https://sms4smile.com/quotes/author/t-colin-campbell/) > [“of oxygen, whether we think of it as ‘good’ or ‘bad’, is the formation of free radicals. As conventionally stated, the idea that breathing…](https://sms4smile.com/quotes/nick-lane/of-oxygen-whether-we-think-of-it-as-good-or-bad-is-the-formation-of/) [Nick Lane](https://sms4smile.com/quotes/author/nick-lane/) > [“Vitamin C also protects other tissues from free-radical damage. Whenever it encounters a free radical, it sacrifices one of its own electrons in order…](https://sms4smile.com/quotes/daniel-p-reid/vitamin-c-also-protects-other-tissues-from-free-radical-damage/) [Daniel P. Reid](https://sms4smile.com/quotes/author/daniel-p-reid/) > [“Free Radicals want to take their careers into their own hands and put the world to work for them. Free Radicals are resilient, self-reliant,…](https://sms4smile.com/quotes/jocelyn-k-glei/free-radicals-want-to-take-their-careers-into-their-own-hands-and-put/) [Jocelyn K. Glei](https://sms4smile.com/quotes/author/jocelyn-k-glei/) ## More by David Perlmutter > [“if you cannot control your hunger and appetite, good luck managing your blood chemistry, metabolism, waistline, and, in the bigger picture, the prospect of…](https://sms4smile.com/quotes/david-perlmutter/if-you-cannot-control-your-hunger-and-appetite-good-luck-managing/) [David Perlmutter](https://sms4smile.com/quotes/author/david-perlmutter/) > [“Nine times out of ten, people pick the wrong food. No, it’s not the sugar (GI = 68), it’s not the candy bar (GI…](https://sms4smile.com/quotes/david-perlmutter/nine-times-out-of-ten-people-pick-the-wrong-food-no-it-s-not-the/) [David Perlmutter](https://sms4smile.com/quotes/author/david-perlmutter/) > [“Your brain… weighs three pounds and has one hundred thousand miles of blood vessels. contains more connections than there are stars in the Milky…](https://sms4smile.com/quotes/david-perlmutter/your-brain-weighs-three-pounds-and-has-one-hundred-thousand-miles-of/) [David Perlmutter](https://sms4smile.com/quotes/author/david-perlmutter/) > [Inflammation is the cornerstone of Alzheimer's disease and Parkinson's, multiple sclerosis - all of the neurodegenerative diseases are really predicated on inflammation.](https://sms4smile.com/quotes/david-perlmutter/inflammation-is-the-cornerstone-of-alzheimer-s-disease-and-parkinson/) [David Perlmutter](https://sms4smile.com/quotes/author/david-perlmutter/) > [“Those who experience symptoms complain of abdominal pain, nausea, diarrhea, constipation, and intestinal distress. Some people, however, don’t experience obvious signs of gastrointestinal trouble,…](https://sms4smile.com/quotes/david-perlmutter/those-who-experience-symptoms-complain-of-abdominal-pain-nausea/) [David Perlmutter](https://sms4smile.com/quotes/author/david-perlmutter/) > [Saturated fat is a fundamental building block for brain cells. It's certainly interesting to consider that one of the richest sources of saturated fat…](https://sms4smile.com/quotes/david-perlmutter/saturated-fat-is-a-fundamental-building-block-for-brain-cells-it-s/) [David Perlmutter](https://sms4smile.com/quotes/author/david-perlmutter/) > [“THE GLUTEN POLICE The following grains and starches contain gluten: barley bulgur couscous farina graham flour kamut matzo rye semolina spelt triticale wheat wheat…](https://sms4smile.com/quotes/david-perlmutter/the-gluten-police-the-following-grains-and-starches-contain-gluten/) [David Perlmutter](https://sms4smile.com/quotes/author/david-perlmutter/) > [“people with celiac have significantly increased production of free radicals, and they exhibit free radical damage to their fat, protein, and even DNA.16 In…](https://sms4smile.com/quotes/david-perlmutter/people-with-celiac-have-significantly-increased-production-of-free/) [David Perlmutter](https://sms4smile.com/quotes/author/david-perlmutter/) > [“The bile salts secreted by the gallbladder, which are needed for the digestion of fat and, therefore, the absorption of fat-soluble vitamins like A,…](https://sms4smile.com/quotes/david-perlmutter/the-bile-salts-secreted-by-the-gallbladder-which-are-needed-for-the/) [David Perlmutter](https://sms4smile.com/quotes/author/david-perlmutter/) > [“According to the latest research, we owe our tremendous brains to the need to think… and the need to run.”](https://sms4smile.com/quotes/david-perlmutter/according-to-the-latest-research-we-owe-our-tremendous-brains-to-the/) [David Perlmutter](https://sms4smile.com/quotes/author/david-perlmutter/) > [Most grain foods, whether we're talking about quinoa, amaranth, the very popular grains of the day - the reality is they still are associated…](https://sms4smile.com/quotes/david-perlmutter/most-grain-foods-whether-we-re-talking-about-quinoa-amaranth-the-very/) [David Perlmutter](https://sms4smile.com/quotes/author/david-perlmutter/) > [“reduce the risk of LDL oxidation—not necessarily levels of LDL itself. A principal player in that risk of oxidation is higher levels of glucose;…](https://sms4smile.com/quotes/david-perlmutter/reduce-the-risk-of-ldl-oxidation-not-necessarily-levels-of-ldl-itself/) [David Perlmutter](https://sms4smile.com/quotes/author/david-perlmutter/) > [People are getting to this place of understanding that their lifestyle choices actually do matter a whole lot as opposed to this notion that…](https://sms4smile.com/quotes/david-perlmutter/people-are-getting-to-this-place-of-understanding-that-their/) [David Perlmutter](https://sms4smile.com/quotes/author/david-perlmutter/) > [“What you eat & when you eat matter, but so does what order you eat your foods in. Never eat what Dr. Casey Means…](https://sms4smile.com/quotes/david-perlmutter/what-you-eat-when-you-eat-matter-but-so-does-what-order-you-eat-your/) [David Perlmutter](https://sms4smile.com/quotes/author/david-perlmutter/) > [“The results of the study revealed that those individuals in the lowest 10 percent of daily physical activity had a 230 percent increased risk…](https://sms4smile.com/quotes/david-perlmutter/the-results-of-the-study-revealed-that-those-individuals-in-the/) [David Perlmutter](https://sms4smile.com/quotes/author/david-perlmutter/) [Explore all 163 David Perlmutter quotes ](https://sms4smile.com/quotes/author/david-perlmutter/) ## More Bottom line quotes > [Filmmaking, like sex, isn't a polite enterprise. It involves a lot of mess and the bottom line is, if somebody ain't screaming, you're not…](https://sms4smile.com/quotes/james-woods/filmmaking-like-sex-isn-t-a-polite-enterprise-it-involves-a-lot-of/) [James Woods](https://sms4smile.com/quotes/author/james-woods/) > [Cheer up. You're not going to be single forever. Bottom line is, you're young. Don't base your future on your past.](https://sms4smile.com/quotes/anonymous/cheer-up-you-re-not-going-to-be-single-forever-bottom-line-is-you-re/) [Anonymous](https://sms4smile.com/quotes/author/anonymous/) > [I plead with my Moonlight fans to give this show a chance if they let me give it a chance. I can’t do Moonlight…](https://sms4smile.com/quotes/alex-o-loughlin/i-plead-with-my-moonlight-fans-to-give-this-show-a-chance-if-they-let/) [Alex O'Loughlin](https://sms4smile.com/quotes/author/alex-o-loughlin/) > [Well, the bottom line is that I'm extremely pleased with 'The Stupids.' I'm pleased that it's coming out, and it should look good. It's…](https://sms4smile.com/quotes/john-landis/well-the-bottom-line-is-that-i-m-extremely-pleased-with-the-stupids-i/) [John Landis](https://sms4smile.com/quotes/author/john-landis/) > [I would have had a clause in my contract; I would've definitely put some fine print in my contract that said, "If the president…](https://sms4smile.com/quotes/joe-budden/i-would-have-had-a-clause-in-my-contract-i-would-ve-definitely-put/) [Joe Budden](https://sms4smile.com/quotes/author/joe-budden/) > [The bottom line, in the professional level, no matter where you go, there's going to be competition. That's what it is. At the end…](https://sms4smile.com/quotes/scott-tolzien/the-bottom-line-in-the-professional-level-no-matter-where-you-go/) [Scott Tolzien](https://sms4smile.com/quotes/author/scott-tolzien/) > [The political satirist usually votes against their own interests, but the bottom line is that it doesn't really matter.](https://sms4smile.com/quotes/lizz-winstead/the-political-satirist-usually-votes-against-their-own-interests-but/) [Lizz Winstead](https://sms4smile.com/quotes/author/lizz-winstead/) > [I'm very grateful to be where I'm at and be able to play. That's really the bottom line for me. Survival and being able…](https://sms4smile.com/quotes/terry-bozzio/i-m-very-grateful-to-be-where-i-m-at-and-be-able-to-play-that-s/) [Terry Bozzio](https://sms4smile.com/quotes/author/terry-bozzio/) > [Bottom line is, work ethic equals dreams, and I am walking proof that that's a fact.](https://sms4smile.com/quotes/diamond-dallas-page/bottom-line-is-work-ethic-equals-dreams-and-i-am-walking-proof-that/) [Diamond Dallas Page](https://sms4smile.com/quotes/author/diamond-dallas-page/) > [One of two things when the guy you're dating isn't really ready to commit. He's an a\*\*hole and he's cheating on you; bottom line…](https://sms4smile.com/quotes/michael-catherwood/one-of-two-things-when-the-guy-you-re-dating-isn-t-really-ready-to/) [Michael Catherwood](https://sms4smile.com/quotes/author/michael-catherwood/) > [The bottom line on attitude is that a good one helps to increase your possibilities. Pessimists usually get what they expect. So do optimists.](https://sms4smile.com/quotes/john-c-maxwell/the-bottom-line-on-attitude-is-that-a-good-one-helps-to-increase-your/) [John C. Maxwell](https://sms4smile.com/quotes/author/john-c-maxwell/) > [If you look at the statistics, I genuinely understand why when we go to a production company or a broadcaster, and they say our…](https://sms4smile.com/quotes/joivan-wade/if-you-look-at-the-statistics-i-genuinely-understand-why-when-we-go/) [Joivan Wade](https://sms4smile.com/quotes/author/joivan-wade/) > [With a reality show, the bottom line is, there's no plot; there's no finale.](https://sms4smile.com/quotes/kate-gosselin/with-a-reality-show-the-bottom-line-is-there-s-no-plot-there-s-no/) [Kate Gosselin](https://sms4smile.com/quotes/author/kate-gosselin/) > [Two to 4% of cancers respond to chemotherapy…The bottom line is for a few kinds of cancer chemo is a life extending procedure-Hodgkin's disease,…](https://sms4smile.com/quotes/ralph-w-moss/two-to-4-of-cancers-respond-to-chemotherapy-the-bottom-line-is-for-a/) [Ralph W. Moss](https://sms4smile.com/quotes/author/ralph-w-moss/) > [The bottom line is that (a) people are never perfect, but love can be, (b) that is the one and only way that the…](https://sms4smile.com/quotes/tom-robbins/the-bottom-line-is-that-a-people-are-never-perfect-but-love-can-be-b/) [Tom Robbins](https://sms4smile.com/quotes/author/tom-robbins/) [Browse all 942 Bottom line quotes ](https://sms4smile.com/quotes/about/bottom-line/) ```json { "@context": "https://schema.org", "@graph": [ { "@type": "Quotation", "text": "“The bottom line is that if you want to reduce oxidative stress and the action of free radicals harming your brain, you have to reduce the glycation of proteins. Which is to say, you have to diminish the availability of sugar. 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