--- title: "Meaning & Key Takeaway of: people who have the genes for unipolar…" description: "\"“people who have the genes for unipolar major depression cannot turn off their stress response. When they experience stress from jobs, deadlines, famil..." image: "https://sms4smile.com/quotes/i/45d/burgess-wes-83133_every-day_people-who-have-the-genes-for-unipolar-m_787912.jpg" --- # people who have the genes for unipolar major depression… ![“people who have the genes for unipolar major depression cannot turn off their stress response. When they experience stress from jobs, deadlines, family trouble, medical illness, or extreme excitement, large quantities of steroid stress hormones and norepinephrine come pouring into their brains and…” quote by Burgess,, Wes](https://sms4smile.com/quotes/i/45d/burgess-wes-83133_every-day_people-who-have-the-genes-for-unipolar-m_787912.jpg) [Download](https://sms4smile.com/quotes/i/45d/burgess-wes-83133_every-day_people-who-have-the-genes-for-unipolar-m_787912.jpg) [Open image](https://sms4smile.com/quotes/i/45d/burgess-wes-83133_every-day_people-who-have-the-genes-for-unipolar-m_787912.jpg) > ““people who have the genes for unipolar major depression cannot turn off their stress response. When they experience stress from jobs, deadlines, family trouble, medical illness, or extreme excitement, large quantities of steroid stress hormones and norepinephrine come pouring into their brains and cannot be stopped. Every day, this stress overload is fatiguing and killing cells in their brains, bringing on unipolar major depression.”” [Burgess,, Wes](https://sms4smile.com/quotes/author/burgess-wes/) ## About This Quote This interpretation was drafted with AI assistance. It is one reading of the quote, not the author's own explanation. Genetic predisposition to depression makes stress response hard to shut down, leading to brain fatigue. **In simple terms:** Stress can trigger depression in vulnerable people. Key Takeaway Manage stress and seek support early. Themes mental health genetics stress Mood concerned empathetic Type clinical educational When to use this quote - workplace - family - medical treatment - therapy - self‑care Key Concepts Neurobiology psychology Questions to Reflect On - What stressors affect you most? - How can you reduce chronic stress? A Different Perspective Stress alone may not cause depression without other factors. ★ ★ ★ ★ ★ No ratings yet [Every day](https://sms4smile.com/quotes/about/every-day/) [Family](https://sms4smile.com/quotes/about/family/) [Family Trouble](https://sms4smile.com/quotes/about/family-trouble-218032/) [Genes Unipolar](https://sms4smile.com/quotes/about/genes-unipolar-6058162/) [Major Depression](https://sms4smile.com/quotes/about/major-depression/) [Mental health](https://sms4smile.com/quotes/about/mental-health/) [Steroid Stress](https://sms4smile.com/quotes/about/steroid-stress-6058163/) [Stress](https://sms4smile.com/quotes/about/stress/) [Stress Hormones](https://sms4smile.com/quotes/about/stress-hormones-1465853/) ## Related quotes > [“Narcissistic Parents often enlist other family members on their side, causing rifts and building alliances against a “bad” child. In other words, they may…](https://sms4smile.com/quotes/joseph-burgo/narcissistic-parents-often-enlist-other-family-members-on-their-side/) [Joseph Burgo](https://sms4smile.com/quotes/author/joseph-burgo/) > [I grew up in the '50s, a tough time for African Americans. I had friends whose fathers would openly say, 'Just bite your tongu;,…](https://sms4smile.com/quotes/gregory-hines/i-grew-up-in-the-50s-a-tough-time-for-african-americans-i-had-friends/) [Gregory Hines](https://sms4smile.com/quotes/author/gregory-hines/) > [“Family trouble was the worst kind. Some families ran their own little versions of the Middle East.”](https://sms4smile.com/quotes/tom-robbins/family-trouble-was-the-worst-kind-some-families-ran-their-own-little/) [Tom Robbins](https://sms4smile.com/quotes/author/tom-robbins/) > [“Give me a clue \| Answer 18. A Family in Trouble A father is sent to jail and the mother will have to sell…](https://sms4smile.com/quotes/puzzleland/give-me-a-clue-answer-18-a-family-in-trouble-a-father-is-sent-to-jail/) [Puzzleland](https://sms4smile.com/quotes/author/puzzleland/) > [“My husband and I have been a part of the same small group for the past five years… Like many small groups, we regularly…](https://sms4smile.com/quotes/timothy-s-lane/my-husband-and-i-have-been-a-part-of-the-same-small-group-for-the/) [Timothy S. Lane](https://sms4smile.com/quotes/author/timothy-s-lane/) > [“You must teach the child of the signs that come to the women of our family when there is trouble and death to be.”](https://sms4smile.com/quotes/betty-smith/you-must-teach-the-child-of-the-signs-that-come-to-the-women-of-our/) [Betty Smith](https://sms4smile.com/quotes/author/betty-smith/) > [What people really want to know from their doctor is, are you going to make me feel better? And what they really want to…](https://sms4smile.com/quotes/john-kasich/what-people-really-want-to-know-from-their-doctor-is-are-you-going-to/) [John Kasich](https://sms4smile.com/quotes/author/john-kasich/) > [And lastly, when other things in life get tough, when you're going through family troubles, when you're heartbroken, when you're frustrated with money problems,…](https://sms4smile.com/quotes/teresita-fernandez/and-lastly-when-other-things-in-life-get-tough-when-you-re-going/) [Teresita Fernandez](https://sms4smile.com/quotes/author/teresita-fernandez/) > [“As Nicholas Kristof put it in The New York Times: “Cues of a hostile or indifferent environment flood an infant, or even a fetus,…](https://sms4smile.com/quotes/arianna-huffington/as-nicholas-kristof-put-it-in-the-new-york-times-cues-of-a-hostile-or/) [Arianna Huffington](https://sms4smile.com/quotes/author/arianna-huffington/) > [When you cry, you release stress hormones, which is why you feel better after crying.](https://sms4smile.com/quotes/anonymous/when-you-cry-you-release-stress-hormones-which-is-why-you-feel-better/) [Anonymous](https://sms4smile.com/quotes/author/anonymous/) > [The stress response is incredibly ancient evolutionarily. Fish, birds and reptiles secrete the same stress hormones we do, yet their metabolism doesn't get messed…](https://sms4smile.com/quotes/robert-sapolsky/the-stress-response-is-incredibly-ancient-evolutionarily-fish-birds/) [Robert Sapolsky](https://sms4smile.com/quotes/author/robert-sapolsky/) > [There is a lot of new research about how stress hormones affect your body and how you can work on giving your body as…](https://sms4smile.com/quotes/ane-brun/there-is-a-lot-of-new-research-about-how-stress-hormones-affect-your/) [Ane Brun](https://sms4smile.com/quotes/author/ane-brun/) > [“Always a mistake to neutralize anxiety with alcohol. It actually raises the production of stress hormones.”](https://sms4smile.com/quotes/fiona-neill/always-a-mistake-to-neutralize-anxiety-with-alcohol-it-actually/) [Fiona Neill](https://sms4smile.com/quotes/author/fiona-neill/) > [My lab looks at the ability of stress hormones to kill brain cells, and basically we are trying to understand on a molecular level…](https://sms4smile.com/quotes/robert-sapolsky/my-lab-looks-at-the-ability-of-stress-hormones-to-kill-brain-cells/) [Robert Sapolsky](https://sms4smile.com/quotes/author/robert-sapolsky/) > [“The stress hormones of adrenaline and cortisol, when pumped in sufficient quantity, rival anything you can smoke or swallow. Within a year of the…](https://sms4smile.com/quotes/erin-kelly/the-stress-hormones-of-adrenaline-and-cortisol-when-pumped-in/) [Erin Kelly](https://sms4smile.com/quotes/author/erin-kelly/) ## More by Burgess,, Wes > [“senses could be dulled, and you might withdraw into yourself, feeling numb and empty.”](https://sms4smile.com/quotes/burgess-wes/senses-could-be-dulled-and-you-might-withdraw-into-yourself-feeling/) [Burgess,, Wes](https://sms4smile.com/quotes/author/burgess-wes/) > [“The genes for depression cause peoples' brains to overreact to stress.”](https://sms4smile.com/quotes/burgess-wes/the-genes-for-depression-cause-peoples-brains-to-overreact-to-stress/) [Burgess,, Wes](https://sms4smile.com/quotes/author/burgess-wes/) [Explore all 3 Burgess,, Wes quotes ](https://sms4smile.com/quotes/author/burgess-wes/) ## More Every day quotes > [“Don’t allow anyone to pressure you into taking a job in a field that doesn’t feel right in your gut. You are the one…](https://sms4smile.com/quotes/alison-james/don-t-allow-anyone-to-pressure-you-into-taking-a-job-in-a-field-that/) [Alison James](https://sms4smile.com/quotes/author/alison-james/) > [OBSESSED, p.p. Vexed by an evil spirit, like the Gadarene swine and other critics. Obsession was once more common than it is now. Arasthus…](https://sms4smile.com/quotes/ambrose-bierce/obsessed-p-p-vexed-by-an-evil-spirit-like-the-gadarene-swine-and/) [Ambrose Bierce](https://sms4smile.com/quotes/author/ambrose-bierce/) > [I loved the game so much that even though our playing field was muddy and we had many trees on it, I used to…](https://sms4smile.com/quotes/roberto-clemente/i-loved-the-game-so-much-that-even-though-our-playing-field-was-muddy/) [Roberto Clemente](https://sms4smile.com/quotes/author/roberto-clemente/) > [On stage, you can bring all those strong emotions that you don't have the opportunity to live. You don't want to die for love…](https://sms4smile.com/quotes/sylvie-guillem/on-stage-you-can-bring-all-those-strong-emotions-that-you-don-t-have/) [Sylvie Guillem](https://sms4smile.com/quotes/author/sylvie-guillem/) > [A real Christian in an odd number anyway. He feels supreme love for One whom he has never seen, talks familiarly every day to…](https://sms4smile.com/quotes/anonymous/a-real-christian-in-an-odd-number-anyway-he-feels-supreme-love-for/) [Anonymous](https://sms4smile.com/quotes/author/anonymous/) > [I think naturally I've been kind of a lead-by-doing guy. Just showing up to work every day. You never ask teammates something you wouldn't…](https://sms4smile.com/quotes/terrell-suggs/i-think-naturally-i-ve-been-kind-of-a-lead-by-doing-guy-just-showing/) [Terrell Suggs](https://sms4smile.com/quotes/author/terrell-suggs/) > [Love is the Key started in 1994 with a simple idea: that Love is the Key that would open all the doors in life.…](https://sms4smile.com/quotes/love-is-the-key/love-is-the-key-started-in-1994-with-a-simple-idea-that-love-is-the/) [Love Is The Key®](https://sms4smile.com/quotes/author/love-is-the-key/) > [Being under-recruited coming out of Highland, I've carried that with me. I keep pushing forward, keep working hard every day, keep my head on…](https://sms4smile.com/quotes/mike-daniels/being-under-recruited-coming-out-of-highland-i-ve-carried-that-with/) [Mike Daniels](https://sms4smile.com/quotes/author/mike-daniels/) > [“(one would say yes, if not every day, at least fairly regularly), whether only for yourself or also for others (often only for yourself,…](https://sms4smile.com/quotes/italo-calvino/one-would-say-yes-if-not-every-day-at-least-fairly-regularly-whether/) [Italo Calvino](https://sms4smile.com/quotes/author/italo-calvino/) > [“Are you sure?" he asked in a low voice. "Because if I had the chance... I would spend every moment of every day with…](https://sms4smile.com/quotes/alexandra-monir/are-you-sure-he-asked-in-a-low-voice-because-if-i-had-the-chance-i/) [Alexandra Monir](https://sms4smile.com/quotes/author/alexandra-monir/) > [I don't think I've ever bench-pressed anything in my life. Until about two years ago I swam a mile almost every day. Then I…](https://sms4smile.com/quotes/nick-antosca/i-don-t-think-i-ve-ever-bench-pressed-anything-in-my-life-until-about/) [Nick Antosca](https://sms4smile.com/quotes/author/nick-antosca/) > [I have to justify my job every day.](https://sms4smile.com/quotes/marco-silva/i-have-to-justify-my-job-every-day/) [Marco Silva](https://sms4smile.com/quotes/author/marco-silva/) > [Merlin' was awesome, but the costumes would drive you insane. Every day, you'd get into chain mail and wear 30 pounds of that stuff.](https://sms4smile.com/quotes/eoin-macken/merlin-was-awesome-but-the-costumes-would-drive-you-insane-every-day/) [Eoin Macken](https://sms4smile.com/quotes/author/eoin-macken/) > [This cold weather has set all the young Folks to providing Bedfellows. I have signed two or three Licences every Day \[as a Fairfax…](https://sms4smile.com/quotes/george-mason/this-cold-weather-has-set-all-the-young-folks-to-providing-bedfellows/) [George Mason](https://sms4smile.com/quotes/author/george-mason/) > [I work every day. Sometimes I don't accomplish anything every day, but if I don't work every day, I get depressed and get afraid…](https://sms4smile.com/quotes/joan-didion/i-work-every-day-sometimes-i-don-t-accomplish-anything-every-day-but/) [Joan Didion](https://sms4smile.com/quotes/author/joan-didion/) [Browse all 16,614 Every day quotes ](https://sms4smile.com/quotes/about/every-day/) ```json { "@context": "https://schema.org", "@graph": [ { "@type": "Quotation", "text": "“people who have the genes for unipolar major depression cannot turn off their stress response. When they experience stress from jobs, deadlines, family trouble, medical illness, or extreme excitement, large quantities of steroid stress hormones and norepinephrine come pouring into their brains and cannot be stopped. Every day, this stress overload is fatiguing and killing cells in their brains, bringing on unipolar major depression.”", "creator": { "@type": "Person", "name": "Burgess,, Wes" }, "isPartOf": { "@id": "https://sms4smile.com/quotes/#website" }, "url": "https://sms4smile.com/quotes/burgess-wes/people-who-have-the-genes-for-unipolar-major-depression-cannot-turn/", "about": { "@type": "Thing", "name": "Every day" }, "@id": "https://sms4smile.com/quotes/burgess-wes/people-who-have-the-genes-for-unipolar-major-depression-cannot-turn/#quotation", "image": { "@type": "ImageObject", "@id": "https://sms4smile.com/quotes/i/45d/burgess-wes-83133_every-day_people-who-have-the-genes-for-unipolar-m_787912.jpg", "contentUrl": "https://sms4smile.com/quotes/i/45d/burgess-wes-83133_every-day_people-who-have-the-genes-for-unipolar-m_787912.jpg", "url": "https://sms4smile.com/quotes/i/45d/burgess-wes-83133_every-day_people-who-have-the-genes-for-unipolar-m_787912.jpg", "width": 1080, "height": 1080, "caption": "“people who have the genes for unipolar major depression cannot turn off their stress response. When they…” — Burgess,, Wes", "creditText": "SMS4Smile Quotes", "creator": { "@id": "https://sms4smile.com/quotes/#organization" } } }, { "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://sms4smile.com/" }, { "@type": "ListItem", "position": 2, "name": "Quotes", "item": "https://sms4smile.com/quotes/" }, { "@type": "ListItem", "position": 3, "name": "Burgess,, Wes", "item": "https://sms4smile.com/quotes/author/burgess-wes/" }, { "@type": "ListItem", "position": 4, "name": "“people who have the genes for...", "item": "https://sms4smile.com/quotes/burgess-wes/people-who-have-the-genes-for-unipolar-major-depression-cannot-turn/" } ], "@id": "https://sms4smile.com/quotes/burgess-wes/people-who-have-the-genes-for-unipolar-major-depression-cannot-turn/#breadcrumb" }, { "@type": "WebSite", "@id": "https://sms4smile.com/quotes/#website", "name": "SMS4Smile Quotes", "url": "https://sms4smile.com/quotes/", "publisher": { "@id": "https://sms4smile.com/quotes/#organization" } }, { "@type": "Organization", "@id": "https://sms4smile.com/quotes/#organization", "name": "SMS4Smile Quotes", "url": "https://sms4smile.com/quotes/", "logo": { "@type": "ImageObject", "url": "https://sms4smile.com/quotes/wp-content/themes/sq/assets/icons/icon-512.png", "width": 512, "height": 512 } } ] } ```