--- title: "Meaning & Key Takeaway of: It's important to say that depression has…" description: "\"It's important to say that depression has biological underpinnings, and that while medications do not seem to create irreversible changes in the brain,..." image: "https://sms4smile.com/quotes/i/031/andrew-solomon-1140_brain_it-s-important-to-say-that-depression-ha_1253933.jpg" --- # It's important to say that depression has biological… ![“It's important to say that depression has biological underpinnings, and that while medications do not seem to create irreversible changes in the brain, repeated depressive episodes do.” quote by Andrew Solomon](https://sms4smile.com/quotes/i/031/andrew-solomon-1140_brain_it-s-important-to-say-that-depression-ha_1253933.jpg) [Download](https://sms4smile.com/quotes/i/031/andrew-solomon-1140_brain_it-s-important-to-say-that-depression-ha_1253933.jpg) [Open image](https://sms4smile.com/quotes/i/031/andrew-solomon-1140_brain_it-s-important-to-say-that-depression-ha_1253933.jpg) > “It's important to say that depression has biological underpinnings, and that while medications do not seem to create irreversible changes in the brain, repeated depressive episodes do.” [Andrew Solomon](https://sms4smile.com/quotes/author/andrew-solomon/) ## About This Quote This interpretation was drafted with AI assistance. It is one reading of the quote, not the author's own explanation. Depression stems from biology; meds are not permanently damaging, but repeated episodes can alter the brain. **In simple terms:** Depression is biological; meds are safe, but repeated episodes harm the brain. Key Takeaway Seek treatment early to prevent brain changes. Themes mental health biology medication prevention Mood concerned hopeful Type educational motivational When to use this quote - therapy - medication management - stress reduction - support networks Key Concepts Neuroplasticity risk of chronicity Questions to Reflect On - How can early intervention reduce long‑term brain impact? - What lifestyle changes support brain health during depression? A Different Perspective Medication alone cannot reverse brain changes caused by repeated depression. ★ ★ ★ ★ ★ No ratings yet [Brain](https://sms4smile.com/quotes/about/brain/) [Depression](https://sms4smile.com/quotes/about/depression/) ## Related quotes > [At heart, I have always been a coper, I've mostly been able to walk around with my wounds safely hidden, and I've always stored…](https://sms4smile.com/quotes/anonymous/at-heart-i-have-always-been-a-coper-i-ve-mostly-been-able-to-walk/) [Anonymous](https://sms4smile.com/quotes/author/anonymous/) > [As a teenager, I struggled a lot, had several major depressive episodes, and ended up dropping out of high school and getting a GED.](https://sms4smile.com/quotes/laura-van-den-berg/as-a-teenager-i-struggled-a-lot-had-several-major-depressive-episodes/) [Laura van den Berg](https://sms4smile.com/quotes/author/laura-van-den-berg/) > [Though many schizophrenics become curiously attached to their delusions, the fading of the nondelusional world puts them in loneliness beyond all reckoning, a fixed…](https://sms4smile.com/quotes/andrew-solomon/though-many-schizophrenics-become-curiously-attached-to-their/) [Andrew Solomon](https://sms4smile.com/quotes/author/andrew-solomon/) > [“I hit walls of past pleasure all the time, and for me past pleasure is much harder to process then past pain...for me the…](https://sms4smile.com/quotes/andrew-solomon/i-hit-walls-of-past-pleasure-all-the-time-and-for-me-past-pleasure-is/) [Andrew Solomon](https://sms4smile.com/quotes/author/andrew-solomon/) > [“Since I am writing a book about depression, I am often asked in social situations to describe my own experiences, and I usually end…](https://sms4smile.com/quotes/andrew-solomon/since-i-am-writing-a-book-about-depression-i-am-often-asked-in-social/) [Andrew Solomon](https://sms4smile.com/quotes/author/andrew-solomon/) > [“In the throws of depression, one reaches a strange point at which it is impossible to see the line between ones own theatricality and…](https://sms4smile.com/quotes/andrew-solomon/in-the-throws-of-depression-one-reaches-a-strange-point-at-which-it/) [Andrew Solomon](https://sms4smile.com/quotes/author/andrew-solomon/) > [Antonin Artaud wrote on one of his drawings, "Never real and always true," and that is how depression feels. You know that it is…](https://sms4smile.com/quotes/andrew-solomon/antonin-artaud-wrote-on-one-of-his-drawings-never-real-and-always/) [Andrew Solomon](https://sms4smile.com/quotes/author/andrew-solomon/) > [“Why in depression" "If we are human, why not have the right to smile, Why in depression, young, and beautiful as earth, Why in…](https://sms4smile.com/quotes/yanilsa-pena/why-in-depression-if-we-are-human-why-not-have-the-right-to-smile-why/) Yanilsa pena > [“Once upon a time, there was a naïve and innocent girl who thought she could tame the beast and live happily ever after. But…](https://sms4smile.com/quotes/nenia-campbell/once-upon-a-time-there-was-a-na-ve-and-innocent-girl-who-thought-she/) [Nenia Campbell](https://sms4smile.com/quotes/author/nenia-campbell/) > [Im tired, tired of putting more effort than you do. Im tired of always having to start the conversation and if I dont, you…](https://sms4smile.com/quotes/anonymous/im-tired-tired-of-putting-more-effort-than-you-do-im-tired-of-always/) [Anonymous](https://sms4smile.com/quotes/author/anonymous/) > [That is the real problem of depression - a condition which will affect an estimated one in five of the population at some point…](https://sms4smile.com/quotes/giles-andreae/that-is-the-real-problem-of-depression-a-condition-which-will-affect/) [Giles Andreae](https://sms4smile.com/quotes/author/giles-andreae/) > [“my stomach turned and burned with the acid of failure”](https://sms4smile.com/quotes/heidi-ames/my-stomach-turned-and-burned-with-the-acid-of-failure/) Heidi Ames > [There's only so much for a man to take...](https://sms4smile.com/quotes/kirsten-gilchrist/there-s-only-so-much-for-a-man-to-take/) Kirsten Gilchrist > [“As ofttimes as it rains on my little spot of earth, you'd think I'd grow accustomed to the gloom.”](https://sms4smile.com/quotes/richelle-e-goodrich/as-ofttimes-as-it-rains-on-my-little-spot-of-earth-you-d-think-i-d/) [Richelle E. Goodrich](https://sms4smile.com/quotes/author/richelle-e-goodrich/) > [These joys were so trifling as to be as imperceptible as grains of gold among the sand, and in moments of depression she saw…](https://sms4smile.com/quotes/leo-tolstoy/these-joys-were-so-trifling-as-to-be-as-imperceptible-as-grains-of/) [Leo Tolstoy](https://sms4smile.com/quotes/author/leo-tolstoy/) ## More by Andrew Solomon > [“If you banish the dragons, you banish the heroes...”](https://sms4smile.com/quotes/andrew-solomon/if-you-banish-the-dragons-you-banish-the-heroes/) [Andrew Solomon](https://sms4smile.com/quotes/author/andrew-solomon/) > [I started traveling out of curiosity, but I have come to believe in travel's political importance, that encouraging a nation's citizenry to travel may…](https://sms4smile.com/quotes/andrew-solomon/i-started-traveling-out-of-curiosity-but-i-have-come-to-believe-in/) [Andrew Solomon](https://sms4smile.com/quotes/author/andrew-solomon/) > [When I was born, the wisdom was that homosexuality was an illness; that it was caused largely by somebody's mother, and a distorted relationship…](https://sms4smile.com/quotes/andrew-solomon/when-i-was-born-the-wisdom-was-that-homosexuality-was-an-illness-that/) [Andrew Solomon](https://sms4smile.com/quotes/author/andrew-solomon/) > [A lot of people are very political when they are young, and then they outgrow it.](https://sms4smile.com/quotes/andrew-solomon/a-lot-of-people-are-very-political-when-they-are-young-and-then-they/) [Andrew Solomon](https://sms4smile.com/quotes/author/andrew-solomon/) > [Having always imagined myself in a fairly slim minority, I suddenly saw that I was in a vast company. Difference unites us. While each…](https://sms4smile.com/quotes/andrew-solomon/having-always-imagined-myself-in-a-fairly-slim-minority-i-suddenly/) [Andrew Solomon](https://sms4smile.com/quotes/author/andrew-solomon/) > [If your love didn't always contain the possibility of loss, it would be very different from human love as we know it.](https://sms4smile.com/quotes/andrew-solomon/if-your-love-didn-t-always-contain-the-possibility-of-loss-it-would/) [Andrew Solomon](https://sms4smile.com/quotes/author/andrew-solomon/) > [Antonin Artaud wrote on one of his drawings, "Never real and always true," and that is how depression feels. You know that it is…](https://sms4smile.com/quotes/andrew-solomon/antonin-artaud-wrote-on-one-of-his-drawings-never-real-and-always/) [Andrew Solomon](https://sms4smile.com/quotes/author/andrew-solomon/) > [I met people on college campuses who were defining themselves as genderqueer to express revolutionary feelings, or to communicate their individuality; they were gender…](https://sms4smile.com/quotes/andrew-solomon/i-met-people-on-college-campuses-who-were-defining-themselves-as/) [Andrew Solomon](https://sms4smile.com/quotes/author/andrew-solomon/) > [“In the throws of depression, one reaches a strange point at which it is impossible to see the line between ones own theatricality and…](https://sms4smile.com/quotes/andrew-solomon/in-the-throws-of-depression-one-reaches-a-strange-point-at-which-it/) [Andrew Solomon](https://sms4smile.com/quotes/author/andrew-solomon/) > [“Since I am writing a book about depression, I am often asked in social situations to describe my own experiences, and I usually end…](https://sms4smile.com/quotes/andrew-solomon/since-i-am-writing-a-book-about-depression-i-am-often-asked-in-social/) [Andrew Solomon](https://sms4smile.com/quotes/author/andrew-solomon/) > [Loving our own children is an exercise for the imagination.](https://sms4smile.com/quotes/andrew-solomon/loving-our-own-children-is-an-exercise-for-the-imagination/) [Andrew Solomon](https://sms4smile.com/quotes/author/andrew-solomon/) > [One the one hand, the simple fact that there are children and that I do have an effect on them has been one of…](https://sms4smile.com/quotes/andrew-solomon/one-the-one-hand-the-simple-fact-that-there-are-children-and-that-i/) [Andrew Solomon](https://sms4smile.com/quotes/author/andrew-solomon/) > [I grew up feeling that to be gay was a tragedy. I didn't grow up thinking that it was morally wrong, but I grew…](https://sms4smile.com/quotes/andrew-solomon/i-grew-up-feeling-that-to-be-gay-was-a-tragedy-i-didn-t-grow-up/) [Andrew Solomon](https://sms4smile.com/quotes/author/andrew-solomon/) > [We need to acknowledge that families come in multiple shapes and sizes, that love is not a finite asset, and that caregiving involves more…](https://sms4smile.com/quotes/andrew-solomon/we-need-to-acknowledge-that-families-come-in-multiple-shapes-and/) [Andrew Solomon](https://sms4smile.com/quotes/author/andrew-solomon/) > [I had always wanted to have children, so it caused me a lot of grief when I was younger, and I had supposed that…](https://sms4smile.com/quotes/andrew-solomon/i-had-always-wanted-to-have-children-so-it-caused-me-a-lot-of-grief/) [Andrew Solomon](https://sms4smile.com/quotes/author/andrew-solomon/) [Explore all 282 Andrew Solomon quotes ](https://sms4smile.com/quotes/author/andrew-solomon/) ## More Brain quotes > [The brain abhors discrepancies.](https://sms4smile.com/quotes/vilayanur-s-ramachandran/the-brain-abhors-discrepancies/) [Vilayanur S. Ramachandran](https://sms4smile.com/quotes/author/vilayanur-s-ramachandran/) > [In some circles where very heavy people think they have very heavy brains, words like "charming" and "clever" and "pretty" are all put-downs; all…](https://sms4smile.com/quotes/andy-warhol/in-some-circles-where-very-heavy-people-think-they-have-very-heavy/) [Andy Warhol](https://sms4smile.com/quotes/author/andy-warhol/) > [Let me tell you that atheism has never painted a masterpiece. Atheism has never dispelled fear. Atheism has never healed a disease; faith in…](https://sms4smile.com/quotes/john-hagee/let-me-tell-you-that-atheism-has-never-painted-a-masterpiece-atheism/) [John Hagee](https://sms4smile.com/quotes/author/john-hagee/) > [down with ought with because with every brain that thinks it thinks nor dares to feel.](https://sms4smile.com/quotes/anonymous/down-with-ought-with-because-with-every-brain-that-thinks-it-thinks/) [Anonymous](https://sms4smile.com/quotes/author/anonymous/) > [To explicate the uses of the Brain seems as difficult a task as to paint the Soul, of which it is commonly said, that…](https://sms4smile.com/quotes/thomas-willis/to-explicate-the-uses-of-the-brain-seems-as-difficult-a-task-as-to/) [Thomas Willis](https://sms4smile.com/quotes/author/thomas-willis/) > [I prefer the word 'musician.' I'm a musician and a composer. I have a problem with the word 'artist.' I don't know if it's…](https://sms4smile.com/quotes/stromae/i-prefer-the-word-musician-i-m-a-musician-and-a-composer-i-have-a/) [Stromae](https://sms4smile.com/quotes/author/stromae/) > [Thinking of sex provides enough mental stimulation to reduce risk of diseases that damage the brain.](https://sms4smile.com/quotes/anonymous/thinking-of-sex-provides-enough-mental-stimulation-to-reduce-risk-of/) [Anonymous](https://sms4smile.com/quotes/author/anonymous/) > [My writing routine is: get son off to school and sit down at 8 A.M. I read what I wrote the day before, and…](https://sms4smile.com/quotes/tracy-chevalier/my-writing-routine-is-get-son-off-to-school-and-sit-down-at-8-a-m-i/) [Tracy Chevalier](https://sms4smile.com/quotes/author/tracy-chevalier/) > [The reason I'm drawn to it is - both the off road racing and the motorcycles on the track - it takes a lot…](https://sms4smile.com/quotes/dax-shepard/the-reason-i-m-drawn-to-it-is-both-the-off-road-racing-and-the/) [Dax Shepard](https://sms4smile.com/quotes/author/dax-shepard/) > [Without illusions. I love you because you are fallible and because your poor misguided testosterone-corrupted brain has you doing cartwheels trying not to be.…](https://sms4smile.com/quotes/cindy-gerard/without-illusions-i-love-you-because-you-are-fallible-and-because/) [Cindy Gerard](https://sms4smile.com/quotes/author/cindy-gerard/) > [being asked to decide between your passion for work and your passion for children was like being asked by your doctor whether you preferred…](https://sms4smile.com/quotes/helen-bevington/being-asked-to-decide-between-your-passion-for-work-and-your-passion/) [Helen Bevington](https://sms4smile.com/quotes/author/helen-bevington/) > [I was told I had brain damage. I always knew it was an unfair label. Now I have a clearer understanding of what's wrong…](https://sms4smile.com/quotes/susan-boyle/i-was-told-i-had-brain-damage-i-always-knew-it-was-an-unfair-label/) [Susan Boyle](https://sms4smile.com/quotes/author/susan-boyle/) > [The act of learning to read added an entirely new circuit to our hominid brain's repertoire. The long developmental process of learning to read…](https://sms4smile.com/quotes/maryanne-wolf/the-act-of-learning-to-read-added-an-entirely-new-circuit-to-our/) [Maryanne Wolf](https://sms4smile.com/quotes/author/maryanne-wolf/) > [I can't let fear kill my creative brain. Fear is the killer. Your bad choices come from fear. And I'm constantly combating fear. I'm…](https://sms4smile.com/quotes/jon-m-chu/i-can-t-let-fear-kill-my-creative-brain-fear-is-the-killer-your-bad/) [Jon M. Chu](https://sms4smile.com/quotes/author/jon-m-chu/) > [I am the way I am. If you like me because I'm glamorous, so be it. If you like me, because I speak well…](https://sms4smile.com/quotes/malaika-arora-khan/i-am-the-way-i-am-if-you-like-me-because-i-m-glamorous-so-be-it-if/) [Malaika Arora Khan](https://sms4smile.com/quotes/author/malaika-arora-khan/) [Browse all 8,465 Brain quotes ](https://sms4smile.com/quotes/about/brain/) ```json { "@context": "https://schema.org", "@graph": [ { "@type": "Quotation", "text": "It's important to say that depression has biological underpinnings, and that while medications do not seem to create irreversible changes in the brain, repeated depressive episodes do.", "creator": { "@type": "Person", "name": "Andrew Solomon" }, "isPartOf": { "@id": "https://sms4smile.com/quotes/#website" }, "url": "https://sms4smile.com/quotes/andrew-solomon/it-s-important-to-say-that-depression-has-biological-underpinnings/", "about": { "@type": "Thing", "name": "Brain" }, "@id": "https://sms4smile.com/quotes/andrew-solomon/it-s-important-to-say-that-depression-has-biological-underpinnings/#quotation", "image": { "@type": "ImageObject", "@id": "https://sms4smile.com/quotes/i/031/andrew-solomon-1140_brain_it-s-important-to-say-that-depression-ha_1253933.jpg", "contentUrl": "https://sms4smile.com/quotes/i/031/andrew-solomon-1140_brain_it-s-important-to-say-that-depression-ha_1253933.jpg", "url": "https://sms4smile.com/quotes/i/031/andrew-solomon-1140_brain_it-s-important-to-say-that-depression-ha_1253933.jpg", "width": 1080, "height": 1080, "caption": "“It's important to say that depression has biological underpinnings, and that while medications do not seem…” — Andrew Solomon", "creditText": "SMS4Smile Quotes", "creator": { "@id": "https://sms4smile.com/quotes/#organization" } } }, { "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://sms4smile.com/" }, { "@type": "ListItem", "position": 2, "name": "Quotes", "item": "https://sms4smile.com/quotes/" }, { "@type": "ListItem", "position": 3, "name": "Andrew Solomon", "item": "https://sms4smile.com/quotes/author/andrew-solomon/" }, { "@type": "ListItem", "position": 4, "name": "It's important to say that depression...", "item": "https://sms4smile.com/quotes/andrew-solomon/it-s-important-to-say-that-depression-has-biological-underpinnings/" } ], "@id": "https://sms4smile.com/quotes/andrew-solomon/it-s-important-to-say-that-depression-has-biological-underpinnings/#breadcrumb" }, { "@type": "WebSite", "@id": "https://sms4smile.com/quotes/#website", "name": "SMS4Smile Quotes", "url": "https://sms4smile.com/quotes/", "publisher": { "@id": "https://sms4smile.com/quotes/#organization" } }, { "@type": "Organization", "@id": "https://sms4smile.com/quotes/#organization", "name": "SMS4Smile Quotes", "url": "https://sms4smile.com/quotes/", "logo": { "@type": "ImageObject", "url": "https://sms4smile.com/quotes/wp-content/themes/sq/assets/icons/icon-512.png", "width": 512, "height": 512 } } ] } ```